Zajkowska Monika, Mroczko Barbara
Department of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland.
Department of Biochemical Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland.
Cancers (Basel). 2021 Jan 3;13(1):128. doi: 10.3390/cancers13010128.
Eotaxins are proteins which belong to the group of cytokines. These small molecules are secreted by cells that are mainly involved in immune-mediated reactions in the course of allergic diseases. Eotaxins were discovered in 1994 and their main role was considered to be the selective recruitment of eosinophils. As those blood cells are involved in the course of all inflammatory diseases, including cancer, we decided to perform an extensive search of the literature pertaining to our investigation via the MEDLINE/PubMed database. On the basis of available literature, we can assume that eotaxins can be used as markers for the detection and determination of origin or type of allergic disease. Many publications also confirm that eotaxins can be used in the determination of allergic disease treatment. Moreover, there are also studies indicating a connection between eotaxins and cancer. Some researchers revealed that CCL11 (C-C motif chemokine ligand 11, eotaxin-1) concentrations differed between the control and tested groups indicating their possible usefulness in cancer detection. Furthermore, some papers showed usefulness of eotaxins in determining the treatment efficacy as markers of decreasing inflammation. Therefore, in this paper we present the current knowledge on eotaxins in the course of allergic and cancerous diseases.
嗜酸性粒细胞趋化因子是属于细胞因子类的蛋白质。这些小分子由主要参与过敏性疾病过程中免疫介导反应的细胞分泌。嗜酸性粒细胞趋化因子于1994年被发现，其主要作用被认为是选择性募集嗜酸性粒细胞。由于这些血细胞参与包括癌症在内的所有炎症性疾病的过程，我们决定通过MEDLINE/PubMed数据库对与我们的研究相关的文献进行广泛检索。根据现有文献，我们可以假设嗜酸性粒细胞趋化因子可作为检测和确定过敏性疾病起源或类型的标志物。许多出版物也证实嗜酸性粒细胞趋化因子可用于确定过敏性疾病的治疗。此外，也有研究表明嗜酸性粒细胞趋化因子与癌症之间存在联系。一些研究人员发现，对照组和测试组之间的CCL11（C-C基序趋化因子配体11，嗜酸性粒细胞趋化因子-1）浓度不同，表明其在癌症检测中可能有用。此外，一些论文表明嗜酸性粒细胞趋化因子作为炎症减轻的标志物在确定治疗效果方面有用。因此，在本文中，我们介绍了关于过敏性疾病和癌症过程中嗜酸性粒细胞趋化因子的当前知识。
