Medicine Department, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria.
Afr Health Sci. 2020 Mar;20(1):294-307. doi: 10.4314/ahs.v20i1.35.
Sex specific differences appear particularly relevant in the management of type 2 DM.
We determined gender specific differences in cardio-metabolic risk, microvascular and macrovascular complications in patients with type 2 diabetes.
Four hundred type 2 diabetes patients, males and females, matched for age and disease duration were recruited from the diabetes clinic. Relevant clinical and laboratory information were obtained or performed.
190(47.5%) were male and 210 (52.5%) were female respectively. The mean age of the study population was 60.6 + 9.93 years. Women had higher prevalence of hypertension (and obesity. Mean total cholesterol was significantly higher in women but men were more likely to achieve LDL treatment goals than women (69.5% vs 59.0%, p<0.05). More women (47.1% & 31.4%) reached glycaemic goals of <10mmol/l for 2HPP and HBA1c of <7.0%.There were no gender differences in the distribution of microvascular and macrovascular complications (p>0.05) but women were more likely to develop moderate and severe diabetic retinopathy (p= 0.027).
Women with T2DM had worse cardiometabolic risk profile with regards to hypertension, obesity and lipid goals. Men achieved therapeutic goals less frequently than did women in terms of glycaemia. Microvascular and macrovascular complications occurred commonly in both sexes.
性别差异在 2 型糖尿病的管理中显得尤为重要。
我们旨在确定 2 型糖尿病患者的心血管代谢风险、微血管和大血管并发症中的性别差异。
从糖尿病诊所招募了 400 名年龄和病程相匹配的男性和女性 2 型糖尿病患者。收集了相关的临床和实验室信息。
190 名（47.5%）为男性，210 名（52.5%）为女性。研究人群的平均年龄为 60.6 ± 9.93 岁。女性高血压（和肥胖症）的患病率更高。女性的总胆固醇均值明显较高，但男性达到 LDL 治疗目标的可能性高于女性（69.5% vs 59.0%，p<0.05）。更多的女性（47.1% 和 31.4%）达到了 2HPP ＜10mmol/l 和 HBA1c ＜7.0%的血糖目标。微血管和大血管并发症的分布在性别间无差异（p>0.05），但女性更易发生中度和重度糖尿病视网膜病变（p=0.027）。
2 型糖尿病女性的心血管代谢风险状况更差，表现为高血压、肥胖和血脂目标。男性在血糖控制方面达到治疗目标的频率低于女性。微血管和大血管并发症在两性中均常见。
