Pei Xiaoting, Huang Duliurui, Li Zhijie
Henan Eye Institute, Henan Eye Hospital, Henan Provincial People's Hospital, People's Hospital of Henan University, People's Hospital of Zhengzhou University, Zhengzhou, China.
Front Genet. 2024 Aug 22;15:1416924. doi: 10.3389/fgene.2024.1416924. eCollection 2024.
Diabetic retinopathy (DR) is a major complication of diabetes worldwide, significantly causing vision loss and blindness in working-age adults, and imposing a substantial socioeconomic burden globally. This review examines the crucial role of genetic factors in the development of DR and highlights the shift toward personalized treatment approaches. Advances in genetic research have identified specific genes and variations involved in angiogenesis, inflammation, and oxidative stress that increase DR susceptibility. Understanding these genetic markers enables early identification of at-risk individuals and the creation of personalized treatment plans. Incorporating these genetic insights, healthcare providers can develop early intervention strategies and tailored treatment plans to improve patient outcomes and minimize side effects. This review emphasizes the transformative potential of integrating genetic information into clinical practice, marking a paradigm shift in DR management and advancing toward a more personalized and effective healthcare model.
糖尿病视网膜病变（DR）是全球糖尿病的主要并发症，在工作年龄段的成年人中显著导致视力丧失和失明，并在全球范围内造成巨大的社会经济负担。本综述探讨了遗传因素在DR发生发展中的关键作用，并强调了向个性化治疗方法的转变。遗传研究的进展已经确定了参与血管生成、炎症和氧化应激的特定基因和变异，这些增加了DR的易感性。了解这些遗传标记能够早期识别高危个体并制定个性化治疗方案。结合这些遗传见解，医疗保健提供者可以制定早期干预策略和量身定制的治疗方案，以改善患者预后并将副作用降至最低。本综述强调了将遗传信息整合到临床实践中的变革潜力，标志着DR管理的范式转变，并朝着更个性化、更有效的医疗模式迈进。
