Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Dermatology, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Dermatol Ther. 2021 Mar;34(2):e14750. doi: 10.1111/dth.14750. Epub 2021 Jan 17.
Vitiligo is a prevalent destructive melanocyte skin disease that negatively affects the patients' life in terms of self-esteem. Suction blister and dermabrasion plus 5-fluorouracil are effective treatments for vitiligo. The present study was conducted to compare the outcomes of these two techniques. The present clinical trial was conducted on 36 patients with persistent refractory vitiligo which defined as the lack of any new or progressed lesion during the previous year as well as no responding to conventional therapies of vitiligo including topical treatments and phototherapy. Individuals with two vitiligo patches, with similar baseline Vitiligo Area Severity Index (VASI) scores were randomly allocated to dermabrasion plus 5-fluorouracil or suction blister treatments. VASI and repigmentation scores were measured and compared at the baseline, four, and 12 weeks after performing the procedures. Both of the approaches accompanied with significant improvement in both entities of VASI and repigmentation scores (P value < .05) at the end of the study, besides the trend of VASI and repigmentation scores between the two groups revealed insignificant difference (P > .05). The short-term follow-up of the patients was the limitation of this study. The present findings suggested that both surgical techniques of dermabrasion plus 5-fluorouracil and suction blister posed acceptable outcomes within 12-week follow-up.
白癜风是一种常见的破坏性黑素细胞皮肤疾病，会对患者的自尊心产生负面影响。吸疱和磨皮加 5-氟尿嘧啶是治疗白癜风的有效方法。本研究旨在比较这两种技术的疗效。本临床试验纳入了 36 例持续性难治性白癜风患者，这些患者定义为在过去一年中没有新的或进展性病变，并且对包括局部治疗和光疗在内的常规白癜风治疗没有反应。每个患者有两个白癜风斑块，具有相似的基线白癜风面积严重指数（VASI）评分，被随机分配到磨皮加 5-氟尿嘧啶或吸疱治疗组。在基线、4 周和 12 周后测量并比较 VASI 和复色评分。两种方法都能显著改善 VASI 和复色评分的两个方面（P 值<.05），在研究结束时，两组之间的 VASI 和复色评分趋势没有显著差异（P>.05）。本研究的局限性在于患者的短期随访。本研究结果表明，磨皮加 5-氟尿嘧啶和吸疱两种手术技术在 12 周随访内都能获得可接受的效果。
