Ozdemir Mustafa, Cetinkale Oğuz, Wolf Ronni, Kotoğyan Agop, Mat Cem, Tüzün Binnur, Tüzün Yalçin
Departments of Dermatology and Plastic Surgery, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, 80200 Turkey.
Int J Dermatol. 2002 Mar;41(3):135-8. doi: 10.1046/j.1365-4362.2002.01391.x.
Surgical techniques have recently been introduced for patients with vitiligo. Randomized controlled trials have not been performed.
To compare the efficacy and side-effects of two surgical methods (suction blister vs. thin split-thickness graft technique) for the treatment of vitiligo.
Three suction blisters, approximately 0.8 cm in diameter, made with a special tool attached to a vacuum extractor, which were converted to erosions by removal of the roofs of the bullae, and one round erosion of approximately the same diameter, made using a silver knife, were created. One roof of a blister and two cutaneous thin split-thickness grafts taken from the gluteal region were transferred onto recipient vitiliginous areas; one was left alone. The results were evaluated by one non-blind and two blind observers bimonthly during the 3-month follow-up period.
Repigmentation rates were 25-65% in the suction blister technique and 90% in the thin split-thickness graft technique (P < 0.001).
The thin split-thickness graft technique is superior to the suction blister technique in treating vitiligo.
近期已为白癜风患者引入了手术技术。尚未进行随机对照试验。
比较两种手术方法（抽吸水疱法与薄断层皮片移植技术）治疗白癜风的疗效和副作用。
用连接在真空吸引器上的特殊工具制作三个直径约0.8厘米的抽吸水疱，通过去除水疱顶部使其变为糜烂面，并用银刀制作一个直径大致相同的圆形糜烂面。将一个水疱的顶部以及取自臀区的两片薄断层皮片移植到白癜风患者的受区；留一个区域不做处理。在3个月的随访期内，由一名非盲观察者和两名盲观察者每两个月评估一次结果。
抽吸水疱法的色素再生率为25% - 65%，薄断层皮片移植技术的色素再生率为90%（P < 0.001）。
在治疗白癜风方面，薄断层皮片移植技术优于抽吸水疱法。
