补充合生制剂对超重和肥胖乳腺癌幸存者血清脂联素和炎症状态的影响：一项随机、三盲、安慰剂对照试验。

Effects of synbiotic supplementation on serum adiponectin and inflammation status of overweight and obese breast cancer survivors: a randomized, triple-blind, placebo-controlled trial.

机构信息

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

Breast Disease Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.

出版信息

Support Care Cancer. 2021 Jul;29(7):4147-4157. doi: 10.1007/s00520-020-05926-8. Epub 2021 Jan 6.

DOI:10.1007/s00520-020-05926-8

PMID:33404812

Abstract

PURPOSE

Adipokines and inflammatory factors can affect breast cancer (BC) prognosis and recurrence among breast cancer survivors (BCSs). This study was to evaluate the effects of synbiotic supplementation along with a low-calorie diet on some recurrence-related factors such as adiponectin, tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) among obese and overweight BCSs.

METHODS

We performed a randomized, triple-blind, placebo-controlled clinical trial among 76 overweight or obese postmenopausal women with a history of hormone-receptor-positive BC. Participants were randomly divided into 2 groups to intake either 10 CFU/day synbiotic supplement or placebo (n = 38 each group) for 8 weeks. All participants were given a low-calorie diet program. The primary outcome was serum concentration of adiponectin which was measured at baseline and after 8 weeks.

RESULTS

Compared with the placebo, synbiotic intake significantly increased adiponectin (+ 13.58 (10.08, 18.17) vs. - 0.42 (- 2.90, 1.98) μg/ml; P < 0.001). In addition, synbiotic supplementation resulted in significant reduction in TNF-α levels (- 17.09 (- 32.05, - 13.60) vs. 0.20 (- 3.97, 2.00) ng/L; P < 0.001) and hs-CRP levels (- 1.14 (- 1.90, - 0.88 vs. - 0.06 (- 0.38, 0.15) mg/L; P < 0.001) compared with the placebo.

CONCLUSIONS

In conclusion, 8-week synbiotic consumption by overweight and obese postmenopausal BCSs had beneficial effects on adiponectin, TNF-α, and hs-CRP.

TRIAL REGISTRATION

IRCT, IRCT20091114002709N49. Registered 18 May 2018, http://www.irct.ir : IRCT20091114002709N49.

摘要

目的

脂肪因子和炎性因子会影响乳腺癌（BC）患者的预后和复发。本研究旨在评估益生菌补充剂联合低热量饮食对肥胖和超重乳腺癌幸存者（BCS）中一些与复发相关的因素的影响，如脂联素、肿瘤坏死因子-α（TNF-α）和高敏 C 反应蛋白（hs-CRP）。

方法

我们对 76 名超重或肥胖、绝经后、有激素受体阳性 BC 病史的女性进行了一项随机、三盲、安慰剂对照的临床试验。参与者被随机分为两组，分别服用 10 亿 CFU/天的益生菌补充剂或安慰剂（每组 n = 38），持续 8 周。所有参与者均接受低热量饮食方案。主要结局指标是基线和 8 周后血清脂联素浓度。

结果

与安慰剂组相比，益生菌组的脂联素显著增加（+13.58（10.08，18.17）比-0.42（-2.90，1.98）μg/ml；P<0.001）。此外，益生菌组 TNF-α水平显著降低（-17.09（-32.05，-13.60）比 0.20（-3.97，2.00）ng/L；P<0.001）和 hs-CRP 水平显著降低（-1.14（-1.90，-0.88）比-0.06（-0.38，0.15）mg/L；P<0.001）与安慰剂组相比。