11 岁至 34 岁期间酒精使用问题和反社会同伴关系的共同发展：选择、社会化以及遗传和环境影响。

Co-development of alcohol use problems and antisocial peer affiliation from ages 11 to 34: selection, socialization and genetic and environmental influences.

机构信息

University of Michigan, Ann Arbor, MI, USA.

Auburn University, Auburn, AL, USA.

出版信息

Addiction. 2021 Aug;116(8):1999-2007. doi: 10.1111/add.15402. Epub 2021 Jan 19.

DOI:10.1111/add.15402

PMID:33405277

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8254734/

Abstract

BACKGROUND AND AIMS

Social context is an important factor in determining the developmental trajectory of alcohol use. We examined the co-development between alcohol use problems and antisocial peer affiliation. We also estimated the genetic and environmental influences on alcohol use problems, antisocial peer affiliation and their co-development over time.

DESIGN

Longitudinal study using bivariate latent basis models with structured residuals (LBM-SR). A biometric model was then fitted to estimate the genetic and environmental influences on the growth factors and their covariances.

SETTING

The United States mid-west region.

PARTICIPANTS

Members of the Minnesota Twin Family Study (MTFS), an ongoing, longitudinal study of 3762 (52% female) twins (1881 pairs).

MEASUREMENTS

Alcohol use problems were assessed using a composite measure of average number of drinks per occasion in the past 12 months, maximum number of drinks in 24 hours and DSM-III-R symptoms of alcohol abuse and dependence. Antisocial peer affiliation was measured by self-report of the proportion of one's friends who exhibited types of antisocial behaviors.

FINDINGS

The LBM-SR model revealed that there was a large correlation between the growth factors for alcohol use problems and antisocial peer affiliation [r = 0.78, 95% confidence interval (CI) = 0.76, 0.80] and cross-lagged effects consistent with both selection and socialization effects. Additionally, antisocial peer affiliation in adolescence was associated with greater increases in alcohol use problems over time (r = 0.57, 95% CI = 0.54, 0.60). Genetic influences largely accounted for the association between antisocial peer affiliation in pre-adolescence and growth in alcohol use problems, while shared environmental influences accounted for the correlation between antisocial peer affiliation and alcohol use problems growth factors.

CONCLUSIONS

Antisocial peer affiliation in adolescence appears to be a salient, genetically influenced risk factor for early alcohol use and increase in alcohol use from adolescence to young adulthood.

摘要

背景与目的

社会环境是决定饮酒行为发展轨迹的重要因素。我们研究了饮酒问题与反社会同伴关系的共同发展。我们还估计了遗传和环境因素对饮酒问题、反社会同伴关系及其随时间的共同发展的影响。

设计

使用具有结构残差的双变量潜在基础模型（LBM-SR）进行纵向研究。然后拟合生物计量模型以估计遗传和环境因素对增长因素及其协方差的影响。

地点

美国中西部地区。

参与者

明尼苏达州双胞胎家庭研究（MTFS）的成员，这是一项正在进行的、对 3762 名（52%为女性）双胞胎（1881 对）进行的纵向研究。

测量

使用过去 12 个月中每次饮酒的平均量、24 小时内最大饮酒量以及 DSM-III-R 酒精滥用和依赖症状的综合指标来评估饮酒问题。反社会同伴关系通过自我报告其朋友中表现出反社会行为类型的比例来衡量。

结果

LBM-SR 模型显示，饮酒问题和反社会同伴关系的增长因素之间存在很大的相关性[r=0.78，95%置信区间（CI）=0.76，0.80]，并且存在交叉滞后效应，与选择和社会化效应一致。此外，青少年时期的反社会同伴关系与随时间推移饮酒问题的增加有关（r=0.57，95%CI=0.54，0.60）。遗传因素在很大程度上解释了青少年期反社会同伴关系与饮酒问题增长之间的关联，而共同环境因素则解释了反社会同伴关系与饮酒问题增长因素之间的相关性。