Workie Yitayal Admassu, Imae Toyoko, Krafft Marie Pierre
Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, 43 Section 4, Keelung Road, Taipei 10607, Taiwan.
Department of Chemical Engineering, National Taiwan University of Science and Technology, 43 Section 4, Keelung Road, Taipei 10607, Taiwan.
ACS Biomater Sci Eng. 2019 Jun 10;5(6):2926-2934. doi: 10.1021/acsbiomaterials.9b00474. Epub 2019 May 6.
In view of preparing effective nitric oxide gas carriers, a fluorinated poly(ethylene glycol) (-PEG) was noncovalently conjugated with acid-treated graphene oxide (GO) to prepare the composite of -PEG@GO. When the persistence of NO gas doped on GO and -PEG@GO was investigated for 3 h, the conserved NO gas decreased from 49.00 ± 7.06 to 2.17 ± 1.36 nmol/mg carrier and from 58.51 ± 6.02 to 4.58 ± 2.22 nmol/mg carrier, respectively. The adsorption of -PEG on GO and the doping of NO on GO and -PEG@GO were declarative by the increase of distance between GO sheets, and the NO doping was also clarified by infrared absorption and X-ray photoelectron spectroscopies. The antibacterial effect was higher for NO-conserved -PEG@GO than for NO-conserved GO and more effective against than against . It is evident that the coating of -PEG on GO is preferable for advancing the loading efficiency, the stability and the biomedical efficacy of NO gas.
为了制备有效的一氧化氮气体载体，将氟化聚乙二醇（-PEG）与酸处理的氧化石墨烯（GO）非共价共轭，以制备-PEG@GO复合材料。当研究掺杂在GO和-PEG@GO上的NO气体的持久性3小时时，保守的NO气体分别从49.00±7.06降至2.17±1.36 nmol/mg载体，以及从58.51±6.02降至4.58±2.22 nmol/mg载体。通过GO片层之间距离的增加表明了-PEG在GO上的吸附以及NO在GO和-PEG@GO上的掺杂，并且通过红外吸收和X射线光电子能谱也阐明了NO掺杂。对于保留NO的-PEG@GO，其抗菌效果高于保留NO的GO，并且对[具体细菌1]比对[具体细菌2]更有效。显然，在GO上包覆-PEG有利于提高NO气体的负载效率、稳定性和生物医学功效。
