Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, 710069, China.
Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, 117574, Singapore.
Adv Healthc Mater. 2016 Aug;5(16):2092-104. doi: 10.1002/adhm.201600357. Epub 2016 Jun 14.
Uniform wüstite Fe0.6 Mn0.4 O nanoflowers have been successfully developed as an innovative theranostic agent with T1 -T2 dual-mode magnetic resonance imaging (MRI), for diagnostic applications and therapeutic interventions via magnetic hyperthermia. Unlike their antiferromagnetic bulk counterpart, the obtained Fe0.6 Mn0.4 O nanoflowers show unique room-temperature ferromagnetic behavior, probably due to the presence of an exchange coupling effect. Combined with the flower-like morphology, ferromagnetic Fe0.6 Mn0.4 O nanoflowers are demonstrated to possess dual-modal MRI sensitivity, with longitudinal relaxivity r1 and transverse relaxivity r2 as high as 4.9 and 61.2 mm(-1) s(-1) [Fe]+[Mn], respectively. Further in vivo MRI carried out on the mouse orthotopic glioma model revealed gliomas are clearly delineated in both T1 - and T2 -weighted MR images, after administration of the Fe0.6 Mn0.4 O nanoflowers. In addition, the Fe0.6 Mn0.4 O nanoflowers also exhibit excellent magnetic induction heating effects. Both in vitro and in vivo magnetic hyperthermia experimentation has demonstrated that magnetic hyperthermia by using the innovative Fe0.6 Mn0.4 O nanoflowers can induce MCF-7 breast cancer cell apoptosis and a complete tumor regression without appreciable side effects. The results have demonstrated that the innovative Fe0.6 Mn0.4 O nanoflowers can be a new magnetic theranostic platform for in vivo T1 -T2 dual-mode MRI and magnetic thermotherapy, thereby achieving a one-stop diagnosis cum effective therapeutic modality in cancer management.
均匀的纤铁矿 Fe0.6Mn0.4O 纳米花已成功开发为一种具有 T1-T2 双模式磁共振成像 (MRI) 的创新治疗诊断剂，用于通过磁热疗进行诊断应用和治疗干预。与反铁磁体块状对应物不同，所获得的 Fe0.6Mn0.4O 纳米花表现出独特的室温铁磁性行为，可能是由于存在交换耦合效应。结合花状形态，铁磁性 Fe0.6Mn0.4O 纳米花表现出双模态 MRI 灵敏度，纵向弛豫率 r1 和横向弛豫率 r2 分别高达 4.9 和 61.2mm-1s-1[Fe]+[Mn]。进一步在原位胶质瘤模型的小鼠体内 MRI 研究表明，在给予 Fe0.6Mn0.4O 纳米花后，T1 和 T2 加权 MR 图像均可清晰描绘出胶质瘤。此外，Fe0.6Mn0.4O 纳米花还表现出优异的磁感应加热效果。体外和体内磁热疗实验均表明，使用创新的 Fe0.6Mn0.4O 纳米花进行磁热疗可以诱导 MCF-7 乳腺癌细胞凋亡并完全消退肿瘤，而没有明显的副作用。这些结果表明，创新的 Fe0.6Mn0.4O 纳米花可以成为体内 T1-T2 双模式 MRI 和磁热疗的新型磁治疗诊断平台，从而在癌症管理中实现一站式诊断和有效治疗方式。
