Ito Yoshihiro
Nano Medical Engineering Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Emergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
ACS Biomater Sci Eng. 2019 Nov 11;5(11):5597-5609. doi: 10.1021/acsbiomaterials.8b01649. Epub 2019 May 1.
Growth factors (GFs) are important for tissue engineering and regenerative medicine because of their interactions with cells and the extracellular matrix. Immobilization of GFs on a matrix is one way to control cell behavior. This review focuses on GF immobilization from the standpoint of chemical immobilization and design of GF proteins. In addition, the total design of environmental factors surrounding cells is discussed for future development of tissue engineering and regenerative medicine.
生长因子（GFs）因其与细胞和细胞外基质的相互作用，在组织工程和再生医学中具有重要意义。将生长因子固定在基质上是控制细胞行为的一种方法。本综述从化学固定和生长因子蛋白质设计的角度重点探讨生长因子的固定化。此外，还讨论了围绕细胞的环境因素的整体设计，以促进组织工程和再生医学的未来发展。
