Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310029, China.
The Affiliated Hospital of Qingdao University and Qingdao Cancer Institute, Qingdao, Shandong 266003, China.
Cell Metab. 2021 Jan 5;33(1):33-50. doi: 10.1016/j.cmet.2020.12.015.
Key pathological, including oncogenic, signaling pathways regulate the canonical functions of metabolic enzymes that serve the cellular metabolic needs. Importantly, these signaling pathways also confer a large number of metabolic enzymes to have noncanonical or nonmetabolic functions that are referred to as "moonlighting" functions. In this review, we highlight how aberrantly regulated metabolic enzymes with such activities play critical roles in the governing of a wide spectrum of instrumental cellular activities, including gene expression, cell-cycle progression, DNA repair, cell proliferation, survival, apoptosis, and tumor microenvironment remodeling, thereby promoting the pathologic progression of disease, including cancer.
关键的病理（包括致癌）信号通路调节代谢酶的经典功能，以满足细胞的代谢需求。重要的是，这些信号通路还赋予大量代谢酶具有非经典或非代谢的功能，这些功能被称为“兼职”功能。在这篇综述中，我们强调了具有这种活性的异常调节代谢酶如何在广泛的仪器细胞活动的调控中发挥关键作用，包括基因表达、细胞周期进展、DNA 修复、细胞增殖、存活、凋亡和肿瘤微环境重塑，从而促进疾病（包括癌症）的病理进展。
