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脂肪细胞微环境:邻里街坊都在谈论温度。

Adipocyte Microenvironment: Everybody in the Neighborhood Talks about the Temperature.

机构信息

Joslin Diabetes Center, Section on Integrative Physiology and Metabolism, Harvard Medical School, Boston, MA, USA.

Joslin Diabetes Center, Section on Integrative Physiology and Metabolism, Harvard Medical School, Boston, MA, USA.

出版信息

Cell Metab. 2021 Jan 5;33(1):4-6. doi: 10.1016/j.cmet.2020.12.012.

DOI:10.1016/j.cmet.2020.12.012
PMID:33406404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7955659/
Abstract

Adipose tissue is composed of a variety of cells distributed in different depots and playing various metabolic roles. In a recent issue of Nature, Sun et al. (2020) use snRNA-seq and functional studies to identify a population of adipocytes that can suppress the thermogenic activity of neighboring adipocytes by secretion of acetate.

摘要

脂肪组织由分布在不同部位的多种细胞组成,发挥着各种代谢作用。在最近的一期《自然》杂志上,Sun 等人(2020 年)利用 snRNA-seq 和功能研究鉴定出一种脂肪细胞群体,它可以通过分泌乙酸来抑制邻近脂肪细胞的产热活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe7/7955659/35c884f1b476/nihms-1670807-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe7/7955659/35c884f1b476/nihms-1670807-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe7/7955659/35c884f1b476/nihms-1670807-f0001.jpg

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本文引用的文献

1
snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis.snRNA-seq 揭示了调节产热的脂肪细胞亚群。
Nature. 2020 Nov;587(7832):98-102. doi: 10.1038/s41586-020-2856-x. Epub 2020 Oct 28.
2
The Heating Microenvironment: Intercellular Cross Talk Within Thermogenic Adipose Tissue.加热微环境:产热脂肪组织中的细胞间串扰。
Diabetes. 2020 Aug;69(8):1599-1604. doi: 10.2337/db20-0303.
3
Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells.人类脂肪细胞亚型的多样化来源于转录上不同的间充质祖细胞。
Adv Sci (Weinh). 2023 Apr;10(12):e2207152. doi: 10.1002/advs.202207152. Epub 2023 Feb 8.
4
Inflammation Related to Obesity in the Etiopathogenesis of Gastroenteropancreatic Neuroendocrine Neoplasms.胃肠胰神经内分泌肿瘤发病机制中与肥胖相关的炎症
Biomedicines. 2022 Oct 21;10(10):2660. doi: 10.3390/biomedicines10102660.
5
Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non- and anti-adipogenic in age-dependent manner.哺乳动物脂肪生成调节剂 (Areg) 细胞通过视黄酸信号以非脂肪生成和抗脂肪生成的方式随年龄增长而变化。
EMBO J. 2022 Sep 15;41(18):e108206. doi: 10.15252/embj.2021108206. Epub 2022 Aug 22.
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Local acetate inhibits brown adipose tissue function.局部醋酸盐抑制棕色脂肪组织功能。
Proc Natl Acad Sci U S A. 2021 Dec 7;118(49). doi: 10.1073/pnas.2116125118.
7
Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual.冷响应脂肪祖细胞将肾上腺素能信号传递到免疫细胞激活,以促进米色脂肪细胞的积累。
Genes Dev. 2021 Oct 1;35(19-20):1333-1338. doi: 10.1101/gad.348762.121. Epub 2021 Sep 16.
Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17970-17979. doi: 10.1073/pnas.1906512116. Epub 2019 Aug 16.
4
Developmental and functional heterogeneity of white adipocytes within a single fat depot.单个脂肪组织中白色脂肪细胞的发育和功能异质性。
EMBO J. 2019 Feb 1;38(3). doi: 10.15252/embj.201899291. Epub 2018 Dec 10.
5
A stromal cell population that inhibits adipogenesis in mammalian fat depots.一种抑制哺乳动物脂肪组织中脂肪生成的基质细胞群体。
Nature. 2018 Jul;559(7712):103-108. doi: 10.1038/s41586-018-0226-8. Epub 2018 Jun 20.
6
Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial.短链脂肪酸混合物经结肠输注可促进超重/肥胖男性的能量代谢:一项随机交叉试验。
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7
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Clin Sci (Lond). 2016 Nov 1;130(22):2073-2082. doi: 10.1042/CS20160263. Epub 2016 Jul 20.
8
Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate.短链脂肪酸乙酸盐对肝脏脂肪堆积的重编程及脂肪组织的“褐变”
Int J Obes (Lond). 2016 Jun;40(6):955-63. doi: 10.1038/ijo.2016.23. Epub 2016 Feb 12.
9
Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue.视黄醛脱氢酶 1 调节白色脂肪组织中的产热程序。
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Retinaldehyde represses adipogenesis and diet-induced obesity.视黄醛可抑制脂肪生成和饮食诱导的肥胖。
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