Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Genes Dev. 2021 Oct 1;35(19-20):1333-1338. doi: 10.1101/gad.348762.121. Epub 2021 Sep 16.
The full array of cold-responsive cell types within white adipose tissue that drive thermogenic beige adipocyte biogenesis remains undefined. We demonstrate that acute cold challenge elicits striking transcriptomic changes specifically within DPP4+ PDGFRβ+ adipocyte precursor cells, including a β-adrenergic receptor CREB-mediated induction in the expression of the prothermogenic cytokine, Doxycycline-inducible deletion of in PDGFRβ+ cells at the onset of cold exposure attenuates ILC2 accumulation and beige adipocyte accrual. These studies highlight the multifaceted roles for adipocyte progenitors and the ability of select mesenchymal subpopulations to relay neuronal signals to tissue-resident immune cells in order to regulate tissue plasticity.
在白色脂肪组织中，能驱动产热米色脂肪细胞生成的所有冷反应细胞类型仍未被确定。我们证明，急性冷刺激会特别引起 DPP4+PDGFRβ+脂肪前体细胞中明显的转录组变化，包括 CREB 介导的 β-肾上腺素能受体表达的诱导，在冷暴露开始时，Doxycycline 诱导的 PDGFRβ+细胞中的缺失会减弱 ILC2 的积累和米色脂肪细胞的积累。这些研究强调了脂肪祖细胞的多方面作用，以及特定间充质亚群将神经元信号传递给组织驻留免疫细胞以调节组织可塑性的能力。
