Bajas Dorothea, Vlase Gabriela, Mateescu Mădălina, Grad Oana Alexandra, Bunoiu Mădălin, Vlase Titus, Avram Claudiu
Research Centre for Thermal Analysis in Environmental Problems, West University of Timisoara, Pestalozzi Street 16, 300115 Timişoara, Romania.
Research Institute for Renewable Energy, Politehnica University of Timişoara, Piata Victoriei No. 2, 300006 Timişoara, Romania.
Polymers (Basel). 2021 Jan 4;13(1):161. doi: 10.3390/polym13010161.
The aim of this study is to obtain and characterize of alginate-based membranes, as well as to choose the most suitable membrane type for the transdermal release of methotrexate. The paper presents the synthesis of four types of membranes based on alginate to which are added other copolymers (Carbopol, Tween, and Polyvinylpyrrolidone) as well as other components with different roles. Membranes and binary mixtures made between the components used in membrane synthesis and methotrexate are analyzed by thermogravimetric techniques, FTIR and UV spectroscopic techniques as well as SEM. The analyses aim to establish the type of membrane most indicated in the use of the controlled release of methotrexate, namely those membranes in which there are no interactions that could inactivate the active substance. Following these studies, it was concluded that membranes obtained from alginate/alginate and Tw can be used for methotrexate release. The membrane obtained from alginate and carbopol was excluded from the beginning because it is not homogeneous. Regarding the AGP-MTX membrane, it presents interactions with the active substance, carboxylate group interactions argued by TGA and FTIR studies, and interactions that occur in aqueous medium.
本研究的目的是制备并表征基于藻酸盐的膜，以及选择最适合甲氨蝶呤透皮释放的膜类型。本文介绍了四种基于藻酸盐的膜的合成方法，这些膜中添加了其他共聚物（卡波姆、吐温、聚乙烯吡咯烷酮）以及其他具有不同作用的成分。通过热重技术、傅里叶变换红外光谱（FTIR）和紫外光谱技术以及扫描电子显微镜（SEM）对膜以及膜合成中使用的成分与甲氨蝶呤之间形成的二元混合物进行分析。这些分析旨在确定在甲氨蝶呤控释应用中最适用的膜类型，即那些不存在可能使活性物质失活的相互作用的膜。经过这些研究，得出结论：由藻酸盐/藻酸盐和吐温制成的膜可用于甲氨蝶呤的释放。从一开始就排除了由藻酸盐和卡波姆制成的膜，因为它不均匀。对于AGP - MTX膜，它与活性物质存在相互作用，热重分析（TGA）和傅里叶变换红外光谱（FTIR）研究表明存在羧酸盐基团相互作用，以及在水性介质中发生的相互作用。
