Cheng Dan, Wang Jing, Dong Zigang, Li Xiang
Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, Henan, China.
China-US (Henan) Hormel Cancer Institute, No. 127, Dongming Road, Jinshui District, Zhengzhou, 450008, Henan, China.
Cancer Cell Int. 2021 Jan 6;21(1):11. doi: 10.1186/s12935-020-01703-z.
Noncoding RNAs, including long noncoding RNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs (circRNAs), are involved in regulating biological functions. In recent decades, miRNAs and lncRNAs have both inspired a wave of research, but the study of circRNA functions is still in its infancy. Studies have found that circRNAs actively participate in the occurrence and development of various diseases, which emphasizes the importance of circRNAs. Here, we review the features and classification of circRNAs and summarize their functions. Then, we briefly describe how to analyze circRNAs by bioinformatics procedures. In addition, the relationship between circRNAs and cancers is discussed with an emphasis on proving whether circRNAs can be potential biomarkers for the prognosis and diagnosis of cancer.
非编码RNA，包括长链非编码RNA（lncRNA）、微小RNA（miRNA）和环状RNA（circRNA），参与调节生物学功能。近几十年来，miRNA和lncRNA都引发了一波研究热潮，但circRNA功能的研究仍处于起步阶段。研究发现，circRNA积极参与各种疾病的发生和发展，这凸显了circRNA的重要性。在此，我们综述circRNA的特征和分类，并总结它们的功能。然后，我们简要描述如何通过生物信息学程序分析circRNA。此外，还讨论了circRNA与癌症之间的关系，重点是证明circRNA是否可作为癌症预后和诊断的潜在生物标志物。
