Shi Peina, Wan Jiangnan, Song Haojun, Ding Xiaoyun
The Medical School of Ningbo University Ningbo, Zhejiang, China.
The Gastroenterology Department of Ningbo First Hospital Ningbo, Zhejiang, China.
Am J Cancer Res. 2018 Oct 1;8(10):1919-1932. eCollection 2018.
Gastric cancer (GC) ranks as the fourth most common cancer and the third leading cause of cancer-related death worldwide. Circular RNAs (circRNAs) are a new class of long noncoding RNAs characterized by a single-stranded covalently closed loop structure. Emerging evidence reveals the essential function of circRNAs in the occurrence and development of human diseases. Among these, circRNAs are aberrantly expressed in GC and are involved in the progression of GC. In this review, we briefly summarize the current knowledge of the classification, biogenesis and biological functions of circRNAs, with an emphasis on their relationship with GC. As our understanding of the relation between circRNAs and GC advances, more diagnostic and therapeutic protocols will be developed for the prevention and treatment of GC.
胃癌（GC）是全球第四大常见癌症，也是癌症相关死亡的第三大主要原因。环状RNA（circRNAs）是一类新型的长链非编码RNA，其特征在于单链共价闭合环状结构。越来越多的证据揭示了circRNAs在人类疾病发生发展中的重要作用。其中，circRNAs在胃癌中异常表达，并参与胃癌的进展。在这篇综述中，我们简要总结了目前关于circRNAs的分类、生物发生和生物学功能的知识，重点阐述了它们与胃癌的关系。随着我们对circRNAs与胃癌之间关系的认识不断深入，将开发出更多用于胃癌预防和治疗的诊断和治疗方案。
