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康涅狄格化学感觉临床研究中心嗅觉测试和简易嗅觉识别测试评估的嗅觉感知的相关性与一致性

Correlation and agreement of olfactory perception assessed by the Connecticut Chemosensory Clinical Research Center olfactory test and the Brief-Smell Identification Test.

作者信息

Aniteli Marcello Bailarini, Marson Fernando Augusto Lima, Cunha Fernanda Rodrigues, Sakano Eulália

机构信息

Universidade de Campinas, Faculdade de Ciências Médicas, Departamento de Oftalmologia e Otorrinolaringologia, Campinas, SP, Brazil.

Universidade São Francisco, Programa de Pós-Graduação em Ciências da Saúde, Laboratório de Genética Humana e Médica, Bragança Paulista, SP, Brazil.

出版信息

Braz J Otorhinolaryngol. 2022 Nov-Dec;88(6):858-866. doi: 10.1016/j.bjorl.2020.11.013. Epub 2020 Dec 21.

Abstract

INTRODUCTION

Assessing olfactory perception in olfactory disorders is of utmost importance in therapy management. However, the University of Pennsylvania Smell Identification Test and the Sniffin' Sticks are the only tests validated in Brazil.

OBJECTIVES

To evaluate the correlation and agreement between the Chemosensory Clinical Research Center olfactory test and the Brief-Smell Identification Test - University of Pennsylvania Smell Identification Test - in healthy participants and in participants with olfactory disorders based on the results and technical aspects of both tests.

METHODS

Fifty participants without olfactory complaints and 50 participants with olfactory disorders who underwent the Chemosensory Clinical Research Center olfactory test and the Brief-Smell Identification Test were included. The following tests were used for statistical analysis: Mann-Whitney U test, Spearman's correlation, intraclass correlation coefficient and Bland-Altman plot. An alpha error (significance level) of 0.05 was considered in the statistical analysis.

RESULTS

Both tests were effective in distinguishing the groups without the presence of overlapping values ​​for the measured markers. Additionally, there was a strong correlation between Spearman's correlation and intraclass correlation coefficient between the tests and for both nostrils. However, the correlations were lower when the groups were individually evaluated. The Bland-Altman plot showed no bias when all participants were simultaneously evaluated.

CONCLUSIONS

The tests to assess olfactory perception presented a high level of agreement. In our sample, we could infer that the Connecticut Chemosensory Clinical Research Center olfactory test is similar to the Brief-Smell Identification Test and can be used in the routine diagnosis of patients with complaints of olfactory disorders, considering the advantage of its low cost.

摘要

引言

评估嗅觉障碍患者的嗅觉感知对于治疗管理至关重要。然而,宾夕法尼亚大学嗅觉识别测试和嗅棒测试是巴西仅有的经过验证的测试。

目的

基于化学感觉临床研究中心嗅觉测试和简易嗅觉识别测试(宾夕法尼亚大学嗅觉识别测试)的结果及技术方面,评估健康参与者和嗅觉障碍参与者中这两种测试之间的相关性和一致性。

方法

纳入50名无嗅觉主诉的参与者和50名患有嗅觉障碍且接受了化学感觉临床研究中心嗅觉测试和简易嗅觉识别测试的参与者。采用以下测试进行统计分析:曼-惠特尼U检验、斯皮尔曼相关性分析、组内相关系数和布兰德-奥特曼图。统计分析中考虑α错误(显著性水平)为0.05。

结果

两种测试均能有效区分各组,测量指标的值无重叠。此外,两种测试之间以及两个鼻孔之间的斯皮尔曼相关性和组内相关系数存在强相关性。然而,单独评估各组时相关性较低。当同时评估所有参与者时,布兰德-奥特曼图显示无偏差。

结论

评估嗅觉感知的测试显示出高度一致性。在我们的样本中,考虑到其低成本的优势,我们可以推断康涅狄格化学感觉临床研究中心嗅觉测试与简易嗅觉识别测试相似,可用于嗅觉障碍主诉患者的常规诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3896/9615525/d09f88d34e63/gr1.jpg

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