• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

RGD 偶联白藜芦醇 HSA 纳米粒作为一种新型卵巢癌治疗给药系统。

RGD-Conjugated Resveratrol HSA Nanoparticles as a Novel Delivery System in Ovarian Cancer Therapy.

机构信息

Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.

出版信息

Drug Des Devel Ther. 2020 Dec 30;14:5747-5756. doi: 10.2147/DDDT.S248950. eCollection 2020.

DOI:10.2147/DDDT.S248950
PMID:33408463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7779302/
Abstract

BACKGROUND

To establish a novel delivery system of RGD-conjugated resveratrol human serum albumin (HAS) nanoparticles in ovarian cancer therapy.

METHODS

The nanoparticles system was characterized for physicochemical properties, the stability in the serum and in vitro release. The comparison between RVT injection, HSA-RVT NPs and RGD-HSA-RVT NPs regarding tissue distributions and pharmacokinetics was also carried out using mice as the animal models.

RESULTS

The results showed that RGD-HSA-RVT NPs were characterized of small particle size about 128.2 nm and negative zeta potential about -21.42 mV, and drug controlled to release slowly on a biphasic pattern. Compared with control groups, RGD-HSA-RVT NPs showed the higher cellular uptake and cell inhibition rates. In vivo data showed that RGD-HSA-RVT NPs have good tumor enrichment characteristics and a significant difference in tumor inhibition, compared with the control group.

CONCLUSION

RGD-conjugated resveratrol HSA nanoparticles are an ideal drug delivery system, which can play a role in the treatment of ovarian cancer.

摘要

背景

建立一种新型的 RGD 修饰的白藜芦醇人血清白蛋白（HAS）纳米粒递药系统用于卵巢癌治疗。

方法

对纳米粒系统进行理化性质、血清稳定性和体外释放研究。采用小鼠作为动物模型，比较 RVT 注射液、HSA-RVT NPs 和 RGD-HSA-RVT NPs 的组织分布和药代动力学。

结果

结果表明，RGD-HSA-RVT NPs 的粒径约为 128.2nm，Zeta 电位约为-21.42mV，具有双相缓慢释药的特点。与对照组相比，RGD-HSA-RVT NPs 表现出更高的细胞摄取率和细胞抑制率。体内数据表明，与对照组相比，RGD-HSA-RVT NPs 具有良好的肿瘤富集特性和显著的肿瘤抑制作用。

结论

RGD 修饰的白藜芦醇 HAS 纳米粒是一种理想的药物递送系统，可用于卵巢癌的治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1c1/7779302/30d111220ba7/DDDT-14-5747-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1c1/7779302/d408c380811e/DDDT-14-5747-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1c1/7779302/17b239e02610/DDDT-14-5747-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1c1/7779302/434129354eee/DDDT-14-5747-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1c1/7779302/fef630176fa1/DDDT-14-5747-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1c1/7779302/2f8c19424a7c/DDDT-14-5747-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1c1/7779302/30d111220ba7/DDDT-14-5747-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1c1/7779302/d408c380811e/DDDT-14-5747-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1c1/7779302/17b239e02610/DDDT-14-5747-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1c1/7779302/434129354eee/DDDT-14-5747-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1c1/7779302/fef630176fa1/DDDT-14-5747-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1c1/7779302/2f8c19424a7c/DDDT-14-5747-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1c1/7779302/30d111220ba7/DDDT-14-5747-g0006.jpg

相似文献

1
RGD-Conjugated Resveratrol HSA Nanoparticles as a Novel Delivery System in Ovarian Cancer Therapy.RGD 偶联白藜芦醇 HSA 纳米粒作为一种新型卵巢癌治疗给药系统。
Drug Des Devel Ther. 2020 Dec 30;14:5747-5756. doi: 10.2147/DDDT.S248950. eCollection 2020.
2
A Novel Delivery System of RGD-HSA Loaded GEM/CUR Nanoparticles for the Treatment of Pancreatic Cancer Therapy.载 RGD-HSA 的 GEM/CUR 纳米粒新型递药系统用于胰腺癌治疗。
Drug Des Devel Ther. 2022 Jul 26;16:2395-2406. doi: 10.2147/DDDT.S366558. eCollection 2022.
3
Folate-conjugated human serum albumin-encapsulated resveratrol nanoparticles: preparation, characterization, bioavailability and targeting of liver tumors.叶酸偶联人血清白蛋白包裹白藜芦醇纳米粒：制备、表征、生物利用度及肝脏肿瘤靶向性。
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):154-165. doi: 10.1080/21691401.2018.1548468.
4
Anti-tumor efficacy of folate modified PLGA-based nanoparticles for the co-delivery of drugs in ovarian cancer.叶酸修饰的基于聚乳酸-羟基乙酸共聚物的纳米颗粒对卵巢癌药物共递送的抗肿瘤疗效
Drug Des Devel Ther. 2019 Apr 18;13:1271-1280. doi: 10.2147/DDDT.S195493. eCollection 2019.
5
HA/HSA co-modified erlotinib-albumin nanoparticles for lung cancer treatment.用于肺癌治疗的透明质酸/人血清白蛋白共修饰的厄洛替尼-白蛋白纳米粒
Drug Des Devel Ther. 2018 Jul 23;12:2285-2292. doi: 10.2147/DDDT.S169734. eCollection 2018.
6
Pharmacokinetics and in vitro/in vivo antitumor efficacy of aptamer-targeted Ecoflex nanoparticles for docetaxel delivery in ovarian cancer.适体靶向的Ecoflex纳米颗粒用于多西他赛递送治疗卵巢癌的药代动力学及体内外抗肿瘤疗效
Int J Nanomedicine. 2018 Jan 23;13:493-504. doi: 10.2147/IJN.S152474. eCollection 2018.
7
iRGD-Guided Silica/Gold Nanoparticles for Efficient Tumor-Targeting and Enhancing Antitumor Efficacy Against Breast Cancer.iRGD 导向的二氧化硅/金纳米颗粒用于高效肿瘤靶向和增强乳腺癌的抗肿瘤疗效。
Int J Nanomedicine. 2024 Aug 12;19:8237-8251. doi: 10.2147/IJN.S474135. eCollection 2024.
8
Synergistic Effect of Tangeretin and Atorvastatin for Colon Cancer Combination Therapy: Targeted Delivery of These Dual Drugs Using RGD Peptide Decorated Nanocarriers.橘皮素与阿托伐他汀联合治疗结肠癌的协同作用：使用RGD肽修饰的纳米载体靶向递送这两种药物。
Drug Des Devel Ther. 2020 Jul 29;14:3057-3068. doi: 10.2147/DDDT.S256636. eCollection 2020.
9
Carboplatin prodrug conjugated FeO nanoparticles for magnetically targeted drug delivery in ovarian cancer cells.载顺铂前药的 FeO 纳米颗粒用于卵巢癌细胞的磁性靶向药物递送。
J Mater Chem B. 2019 Jan 21;7(3):433-442. doi: 10.1039/c8tb02574f. Epub 2018 Dec 19.
10
Codelivery of GRP78 siRNA and docetaxel via RGD-PEG-DSPE/DOPA/CaP nanoparticles for the treatment of castration-resistant prostate cancer.通过RGD-PEG-DSPE/DOPA/CaP纳米颗粒共递送GRP78 siRNA和多西他赛用于治疗去势抵抗性前列腺癌。
Drug Des Devel Ther. 2019 Apr 29;13:1357-1372. doi: 10.2147/DDDT.S198400. eCollection 2019.

引用本文的文献

1
Ovarian cancer and its management through advanced drug delivery system.卵巢癌及其通过先进药物递送系统的治疗
Med Oncol. 2025 Feb 17;42(3):76. doi: 10.1007/s12032-025-02621-8.
2
Cytotoxic Activity of Curcumin- and Resveratrol-Loaded Core-Shell Systems in Resistant and Sensitive Human Ovarian Cancer Cells.姜黄素和白藜芦醇负载的核壳系统对耐药和敏感人卵巢癌细胞的细胞毒性活性
Int J Mol Sci. 2024 Dec 24;26(1):41. doi: 10.3390/ijms26010041.
3
PLGA-PEG-c(RGDfK)- E Micelles With a Therapeutic Potential for Targeting Ovarian Cancer.具有靶向卵巢癌治疗潜力的聚乳酸-羟基乙酸共聚物-聚乙二醇-环（RGDfK）-E胶束

本文引用的文献

1
Development of Resveratrol-Loaded Herbal Extract-Based Nanocomposites and Their Application to the Therapy of Ovarian Cancer.基于白藜芦醇负载草药提取物的纳米复合材料的研发及其在卵巢癌治疗中的应用。
Nanomaterials (Basel). 2018 May 31;8(6):384. doi: 10.3390/nano8060384.
2
Therapeutic Versatility of Resveratrol Derivatives.白藜芦醇衍生物的治疗多样性。
Nutrients. 2017 Oct 29;9(11):1188. doi: 10.3390/nu9111188.
3
Resveratrol-Loaded Albumin Nanoparticles with Prolonged Blood Circulation and Improved Biocompatibility for Highly Effective Targeted Pancreatic Tumor Therapy.
IET Nanobiotechnol. 2024 Nov 29;2024:7136323. doi: 10.1049/nbt2/7136323. eCollection 2024.
4
Recent development of nanotechnology-based approaches for gynecologic cancer therapy.基于纳米技术的妇科癌症治疗方法的最新进展。
Obstet Gynecol Sci. 2025 Jan;68(1):18-29. doi: 10.5468/ogs.24180. Epub 2024 Nov 26.
5
Advances in the role of resveratrol and its mechanism of action in common gynecological tumors.白藜芦醇在常见妇科肿瘤中的作用及其作用机制的研究进展
Front Pharmacol. 2024 Jul 17;15:1417532. doi: 10.3389/fphar.2024.1417532. eCollection 2024.
6
Trend of albumin nanoparticles in oncology: a bibliometric analysis of research progress and prospects.白蛋白纳米颗粒在肿瘤学中的研究趋势：研究进展与前景的文献计量分析
Front Pharmacol. 2024 Jul 12;15:1409163. doi: 10.3389/fphar.2024.1409163. eCollection 2024.
7
Resveratrol in the Treatment of Gynecological Cancer: Mechanisms and Therapeutic Potential.白藜芦醇在妇科癌症治疗中的作用机制及治疗潜力
Curr Med Chem. 2024 May 3. doi: 10.2174/0109298673290941240430171146.
8
Recent Developments in Nanoparticle Formulations for Resveratrol Encapsulation as an Anticancer Agent.白藜芦醇作为抗癌剂封装的纳米颗粒制剂的最新进展。
Pharmaceuticals (Basel). 2024 Jan 18;17(1):126. doi: 10.3390/ph17010126.
9
Recent Advances in Nanotechnology-Based Targeted Delivery Systems of Active Constituents in Natural Medicines for Cancer Treatment.基于纳米技术的天然药物活性成分靶向传递系统在癌症治疗中的最新进展。
Molecules. 2023 Nov 24;28(23):7767. doi: 10.3390/molecules28237767.
10
Meta-Analysis of Nanoparticle Distribution in Tumors and Major Organs in Tumor-Bearing Mice.肿瘤荷瘤小鼠中肿瘤和主要器官内纳米颗粒分布的荟萃分析。
ACS Nano. 2023 Oct 24;17(20):19810-19831. doi: 10.1021/acsnano.3c04037. Epub 2023 Oct 9.
具有延长血液循环时间和改善生物相容性的白藜芦醇负载白蛋白纳米颗粒用于高效靶向胰腺肿瘤治疗
Nanoscale Res Lett. 2017 Dec;12(1):437. doi: 10.1186/s11671-017-2206-6. Epub 2017 Jun 30.
4
Resveratrol triggers ER stress-mediated apoptosis by disrupting N-linked glycosylation of proteins in ovarian cancer cells.白藜芦醇通过破坏卵巢癌细胞中蛋白质的N-糖基化作用触发内质网应激介导的细胞凋亡。
Cancer Lett. 2016 Feb 28;371(2):347-53. doi: 10.1016/j.canlet.2015.11.032. Epub 2015 Dec 15.
5
Albumin nanoparticles increase the anticancer efficacy of albendazole in ovarian cancer xenograft model.白蛋白纳米颗粒提高了阿苯达唑在卵巢癌异种移植模型中的抗癌疗效。
J Nanobiotechnology. 2015 Mar 25;13:25. doi: 10.1186/s12951-015-0082-8.
6
Preparation, characterization, and in vitro targeted delivery of folate-decorated paclitaxel-loaded bovine serum albumin nanoparticles.叶酸修饰的紫杉醇载牛血清白蛋白纳米粒的制备、表征及体外靶向递药研究。
Int J Nanomedicine. 2010 Sep 20;5:669-77. doi: 10.2147/ijn.s12918.
7
Albumin-bound formulation of paclitaxel (Abraxane ABI-007) in the treatment of breast cancer.白蛋白结合型紫杉醇（Abraxane ABI-007）治疗乳腺癌
Int J Nanomedicine. 2009;4:99-105. doi: 10.2147/ijn.s3061. Epub 2009 Apr 20.
8
Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB).转铁蛋白和转铁蛋白受体抗体修饰的纳米颗粒能够实现药物跨越血脑屏障（BBB）的递送。
Eur J Pharm Biopharm. 2009 Feb;71(2):251-6. doi: 10.1016/j.ejpb.2008.08.021. Epub 2008 Sep 5.
9
Nanotechnology applications in cancer.纳米技术在癌症中的应用。
Annu Rev Biomed Eng. 2007;9:257-88. doi: 10.1146/annurev.bioeng.9.060906.152025.
10
Phase I and pharmacokinetic trial of carboplatin and albumin-bound paclitaxel, ABI-007 (Abraxane) on three treatment schedules in patients with solid tumors.卡铂与白蛋白结合型紫杉醇（ABI-007，商品名Abraxane）针对实体瘤患者的三种治疗方案的I期及药代动力学试验。
Cancer Chemother Pharmacol. 2007 Oct;60(5):759-66. doi: 10.1007/s00280-007-0423-x. Epub 2007 Feb 7.