Lin Jinyong, Huang Zongwei, Lin Xueliang, Wu Qiong, Quan Kerun, Cheng Yanming, Zheng Mingzhi, Xu Jiaying, Dai Yitao, Qiu Hejin, Lin Duo, Feng Shangyuan
Radiation Oncology Department, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou, 350014, China.
Key Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Provincial Key Laboratory for Photonics Technology, Digital Fujian Internet-of-Things Laboratory of Environment Monitoring, Fujian Normal University, Fuzhou, 350007, China.
Biomed Opt Express. 2020 Nov 11;11(12):7109-7119. doi: 10.1364/BOE.406097. eCollection 2020 Dec 1.
The concept of being able to urinate in a cup and screen for colorectal cancer (CRC) is fascinating to the public at large. Here, a simple and label-free urine test based on surface-enhanced Raman spectroscopy (SERS) was employed for CRC detection. Significant spectral differences among normal, stages I-II, and stages III-IV CRC urines were observed. Using discriminant function analysis, the diagnostic sensitivities of 95.8%, 80.9%, and 84.3% for classification of normal, stages I-II, and stages III-IV CRC were achieved in training model, indicating the great promise of urine SERS as a rapid, convenient and noninvasive method for CRC staging detection.
能够通过在杯子中排尿来筛查结直肠癌（CRC）这一概念让广大公众很感兴趣。在此，我们采用了一种基于表面增强拉曼光谱（SERS）的简单且无需标记的尿液检测方法来检测结直肠癌。观察到正常、I-II期以及III-IV期结直肠癌患者尿液之间存在显著的光谱差异。通过判别函数分析，在训练模型中对正常、I-II期以及III-IV期结直肠癌进行分类的诊断灵敏度分别达到了95.8%、80.9%和84.3%，这表明尿液SERS作为一种用于结直肠癌分期检测的快速、便捷且非侵入性方法具有巨大的前景。
