Spiritos Zachary, Abdelmalek Manal F
Division of Gastroenterology and Hepatology, Duke University, Durham, NC, USA.
Transl Gastroenterol Hepatol. 2021 Jan 5;6:13. doi: 10.21037/tgh.2020.02.07. eCollection 2021.
Metabolic syndrome is a major clinical disorder involving metabolic dysregulation characterized clinically with features of central obesity, insulin resistance (IR), type 2 diabetes, hypertension, and dyslipidemia. Metabolic syndrome is strongly associated with the rising prevalence nonalcoholic steatohepatitis, a leading indication for orthotopic liver transplantation in the Western world. The presence or recurrence of metabolic syndrome following liver transplantation can contribute to the development and recurrence of nonalcoholic fatty liver disease (NAFLD) in the liver allograft. In this review, we discuss the endogenous and exogenous drivers of post-transplant metabolic syndrome, role of chronic immunosuppression, and the prevalence and clinical significant of post-transplant metabolic syndrome on nonalcoholic steatohepatitis.
代谢综合征是一种主要的临床疾病，涉及代谢失调，其临床特征为中心性肥胖、胰岛素抵抗（IR）、2型糖尿病、高血压和血脂异常。代谢综合征与非酒精性脂肪性肝炎患病率的上升密切相关，非酒精性脂肪性肝炎是西方世界原位肝移植的主要指征。肝移植后代谢综合征的出现或复发可导致肝移植受者非酒精性脂肪性肝病（NAFLD）的发生和复发。在本综述中，我们讨论了移植后代谢综合征的内源性和外源性驱动因素、慢性免疫抑制的作用，以及移植后代谢综合征在非酒精性脂肪性肝炎中的患病率和临床意义。
