Price S C, Chescoe D, Grasso P, Wright M, Hinton R H
Robens Institute of Industrial and Environmental Health and Safety, University of Surrey, Guildford, U.K.
Toxicol Lett. 1988 Jan;40(1):37-46. doi: 10.1016/0378-4274(88)90181-6.
Treatment of rats for periods of 3 months or longer with the hypolipidaemic drugs clofibrate and fenofibrate or with the plasticiser di-(2-ethylhexyl) phthalate causes alterations in the thyroid. The colloid is shrunken and contains calcium-rich inclusions. Electron microscopy shows increases in the number and size of lysosomes, hypertrophy of the Golgi apparatus and dilation of the rough endoplasmic reticulum. These changes are consistent with persistent hyperactivity in the gland.
用降血脂药物氯贝丁酯和非诺贝特或增塑剂邻苯二甲酸二（2-乙基己基）酯对大鼠进行3个月或更长时间的治疗会导致甲状腺发生改变。甲状腺胶体萎缩并含有富含钙的内含物。电子显微镜检查显示溶酶体的数量和大小增加、高尔基体肥大以及粗面内质网扩张。这些变化与腺体的持续过度活跃一致。
