Wilson D M, Kei J, Hintz R L, Rosenfeld R G
Department of Pediatrics, Stanford (Calif) University 94305.
Am J Dis Child. 1988 Jan;142(1):96-9. doi: 10.1001/archpedi.1988.02150010106035.
We reviewed the effects of a brief course of testosterone enanthate (four intramuscular injections of 200 mg at three-week intervals) on pubertal advancement and final adult height in 50 male patients with delayed puberty. Although those treated with testosterone were slightly older than a group of 38 untreated subjects, the two groups had similar baseline mean bone age delays, height z scores, Tanner stages, predicted adult heights, growth rates, and midparental heights. Four months after baseline, the treated group had a significantly greater mean increase in the height z score and sexual maturation index. At 12 months, the mean increase in the sexual maturation index remained greater in the treated group. Among treated and untreated subjects older than 17 years, there was no significant difference in the absolute height z score. Over 95% of treated subjects were satisfied with the effects of therapy.
我们回顾了庚酸睾酮短期疗程（每三周进行四次200毫克的肌肉注射）对50例青春期延迟男性患者青春期进展及最终成年身高的影响。尽管接受睾酮治疗的患者比38例未治疗的受试者年龄稍大，但两组的基线平均骨龄延迟、身高Z评分、 Tanner分期、预测成年身高、生长速率及父母平均身高相似。基线后四个月，治疗组的身高Z评分和性成熟指数的平均增加显著更大。在12个月时，治疗组的性成熟指数平均增加仍更大。在年龄超过17岁的治疗组和未治疗组受试者中，绝对身高Z评分无显著差异。超过95%的治疗组受试者对治疗效果满意。
