多重耐药非伤寒型人源分离株中的超广谱β-内酰胺酶
Extended-Spectrum β-Lactamases in Human Isolates of Multidrug-Resistant Non-typhoidal .
作者信息
Sedrakyan Anahit M, Ktsoyan Zhanna A, Arakelova Karine A, Zakharyan Magdalina K, Hovhannisyan Alvard I, Gevorgyan Zaruhi U, Mnatsakanyan Armine A, Kakabadze Elene G, Makalatia Khatuna B, Chanishvili Nina A, Pirnay Jean-Paul, Arakelyan Arsen A, Aminov Rustam I
机构信息
Institute of Molecular Biology, National Academy of Sciences of RA, Yerevan, Armenia.
Department of Clinical Laboratory Diagnostics, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia.
出版信息
Front Microbiol. 2020 Dec 22;11:592223. doi: 10.3389/fmicb.2020.592223. eCollection 2020.
A total of 291 non-duplicate isolates of non-typhoidal (NTS) were collected from the fecal samples of patients with salmonellosis in Armenia and Georgia during 1996-2016. The isolates were tested for resistance to antimicrobials, including extended-spectrum β-lactamases (ESBL). The high prevalence of multidrug-resistance (MDR) and ESBL-producer phenotypes was detected among subsp. serovar Typhimurium (. Typhimurium) isolates collected from patients in Armenia between 1996 and 2016. A total of 36 MDR NTS isolates were subjected to whole genome sequencing (WGS) to determine the genetic background of antimicrobial resistance (AMR) and mobile genetic elements. All ESBL-producing . Typhimurium isolates belonged to the same sequence type (ST328). The ESBL-producer phenotype was associated with plasmid-encoded CTX-M-5 production. A range of other plasmids was associated with resistance to other antimicrobials, including the MDR phenotype.
1996年至2016年期间，从亚美尼亚和格鲁吉亚沙门氏菌病患者的粪便样本中总共收集了291株非重复的非伤寒沙门氏菌（NTS）分离株。对这些分离株进行了包括超广谱β-内酰胺酶（ESBL）在内的抗菌药物耐药性检测。在1996年至2016年期间从亚美尼亚患者中收集的鼠伤寒亚种（. Typhimurium）分离株中检测到了高比例的多重耐药（MDR）和产ESBL表型。总共36株MDR NTS分离株进行了全基因组测序（WGS），以确定抗菌药物耐药性（AMR）和移动遗传元件的遗传背景。所有产ESBL的. Typhimurium分离株都属于同一序列类型（ST328）。产ESBL表型与质粒编码的CTX-M-5产生有关。一系列其他质粒与对其他抗菌药物的耐药性有关，包括MDR表型。
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