基于化学发光-微粒免疫检测的巴基斯坦伊斯兰堡地区人类免疫缺陷病毒感染的检测与流行情况。

Chemiluminescent-microparticle-immunoassay-based detection and prevalence of human immunodeficiency virus infection in Islamabad, Pakistan.

机构信息

Department of Biotechnology, Quaid-i-Azam University Islamabad, Islamabad, Pakistan.

Department of Genetics, Hazara University Mansehra, Mansehra, Pakistan.

出版信息

Arch Virol. 2021 Feb;166(2):581-586. doi: 10.1007/s00705-020-04897-9. Epub 2021 Jan 8.

DOI:10.1007/s00705-020-04897-9

PMID:33416997

Abstract

An advanced detection assay is important for clinical diagnosis of human immunodeficiency virus (HIV) infection in asymptomatic individuals. The first step in timely treatment and management of the infection is the early detection of HIV. In this study, we determined the prevalence of HIV in Islamabad for the first time using a chemiluminescent microparticle immunoassay (CMIA), which is an advanced serological diagnostic technique. A total of 3659 samples were obtained from the general public in Islamabad, Pakistan, and 85 of them were found to be positive for HIV infection (2.32% prevalence). Of the positive subjects, 78.82% (67/85) were male, 10.6% (9/85) were female, and 10.6% (9/85) were of unidentified gender. The results revealed a significant relationship between age groups and HIV status. The age group of 21- to 30-year-olds was found to have the highest rate of HIV infection, and the rate of HIV infection in males was higher than in females.

摘要

一种先进的检测方法对于无症状个体的人类免疫缺陷病毒（HIV）感染的临床诊断非常重要。及时治疗和管理感染的第一步是早期检测 HIV。在这项研究中，我们首次使用化学发光微粒子免疫分析（CMIA）来确定巴基斯坦伊斯兰堡的 HIV 流行率，这是一种先进的血清学诊断技术。我们从巴基斯坦伊斯兰堡的普通人群中获得了 3659 个样本，其中 85 个样本 HIV 感染呈阳性（流行率为 2.32%）。在阳性样本中，78.82%（67/85）为男性，10.6%（9/85）为女性，10.6%（9/85）为性别不明。结果表明年龄组与 HIV 状况之间存在显著关系。21 至 30 岁年龄组的 HIV 感染率最高，男性的 HIV 感染率高于女性。