Khanani R M, Hafeez A, Rab S M, Rasheed S
Department of Microbiology, Jinnah Postgraduate Medical Center, Karachi, Pakistan.
AIDS Res Hum Retroviruses. 1988 Apr;4(2):149-54. doi: 10.1089/aid.1988.4.149.
We have documented evidence of the human immunodeficiency virus (HIV) infection in four individuals including a blood donor and three members of a family (husband, wife, and a child) in Karachi, Pakistan. Our data indicate that HIV has been transmitted to the wife of the seropositive male, a drug abuser, in the recent past and that she has passed the virus to her newborn child perinatally/transplacentally. The two seropositive males (blood donor and drug abuser) were diagnosed clinically as having persistent generalized lymphadenopathy, an AIDS-related condition (ARC), and the child presented with developmental disorders and neurologic manifestations. This is the first report of AIDS/ARC cases from Pakistan that can be directly related to HIV infection and its heterosexual transmission.
我们有证据证明在巴基斯坦卡拉奇的4个人感染了人类免疫缺陷病毒（HIV），其中包括一名献血者以及一个家庭的三名成员（丈夫、妻子和一个孩子）。我们的数据表明，HIV最近已传播给一名血清反应呈阳性男性（吸毒者）的妻子，并且她已在围产期/经胎盘将病毒传给了她的新生儿。两名血清反应呈阳性的男性（献血者和吸毒者）临床上被诊断为患有持续性全身性淋巴结肿大，这是一种与艾滋病相关的病症（ARC），而该儿童出现了发育障碍和神经学表现。这是来自巴基斯坦的首例可直接与HIV感染及其异性传播相关的艾滋病/ARC病例报告。
