Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Cell. 2021 Jan 7;184(1):18-32. doi: 10.1016/j.cell.2020.12.002.
Building tissues from scratch to explore entirely new cell configurations could revolutionize fundamental understanding in biology. Bioprinting is an emerging technology to do this. Although typically applied to engineer tissues for therapeutic tissue repair or drug screening, there are many opportunities for bioprinting within biology, such as for exploring cellular crosstalk or cellular morphogenesis. The overall goals of this Primer are to provide an overview of bioprinting with the biologist in mind, outline the steps in extrusion bioprinting (the most widely used and accessible technology), and discuss alternative bioprinting technologies and future opportunities for bioprinting in biology.
从头开始构建组织，探索全新的细胞结构，这可能会彻底改变生物学的基本认识。生物打印是实现这一目标的新兴技术。尽管生物打印通常用于为治疗性组织修复或药物筛选工程组织，但它在生物学中有许多机会，例如探索细胞串扰或细胞形态发生。本入门指南的总体目标是为生物学家提供生物打印概述，概述挤出式生物打印（最广泛使用和易于获取的技术）的步骤，并讨论替代生物打印技术和生物学中生物打印的未来机会。
