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Is speed of processing or working memory the primary information processing deficit in multiple sclerosis?

作者信息

DeLuca John, Chelune Gordon J, Tulsky David S, Lengenfelder Jean, Chiaravalloti Nancy D

机构信息

Kessler Medical Rehabilitation Research and Education Corporation, 1199 Pleasant Valley Way, West Orange, NJ 07052, USA.

出版信息

J Clin Exp Neuropsychol. 2004 Jun;26(4):550-62. doi: 10.1080/13803390490496641.

DOI:10.1080/13803390490496641
PMID:15512942
Abstract

OBJECTIVE

To examine whether processing speed or working memory is the primary information processing deficit in persons with MS.

DESIGN

Case-control study.

SETTING

Hospital-based specialty clinic.

PARTICIPANTS

215 adults with clinically definite MS.

MAIN OUTCOME MEASURE

Mean demographically corrected T-scores, prevalence rates of impairment and relative risk of impaired Processing Speed and Working Memory Index Scores from the WAIS-WMS III.

RESULTS

Deficits in Processing Speed were much more common than Working Memory in all comparisons. This was observed for both relapsing remitting (RRMS) and secondary progressive MS (SPMS) subjects, but accentuated in the latter group.

CONCLUSIONS

Results strongly suggest that the primary information processing deficit in persons with MS is in speed of processing.

摘要

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