Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Int J Epidemiol. 2021 Jul 9;50(3):841-851. doi: 10.1093/ije/dyaa271.
Despite increasing life expectancy (LE), cross-sectional data show widening inequalities in disability-free LE (DFLE) by socioeconomic status (SES) in many countries. We use longitudinal data to better understand trends in DFLE and years independent (IndLE) by SES, and how underlying transitions contribute.
The Cognitive Function and Ageing Studies (CFAS I and II) are large population-based studies of those aged ≥65 years in three English centres (Newcastle, Nottingham, Cambridgeshire), with baseline around 1991 (CFAS I, n = 7635) and 2011 (CFAS II, n = 7762) and 2-year follow-up. We defined disability as difficulty in activities of daily living (ADL), dependency by combining ADLs and cognition reflecting care required, and SES by area-level deprivation. Transitions between disability or dependency states and death were estimated from multistate models.
Between 1991 and 2011, gains in DFLE at age 65 were greatest for the most advantaged men and women [men: 4.7 years, 95% confidence interval (95% CI) 3.3-6.2; women: 2.8 years, 95% CI 1.3-4.3]. Gains were due to the most advantaged women having a reduced risk of incident disability [relative risk ratio (RRR):0.7, 95% CI 0.5-0.8], whereas the most advantaged men had a greater likelihood of recovery (RRR: 1.8, 95% CI 1.0-3.2) and reduced disability-free mortality risk (RRR: 0.4, 95% CI 0.3-0.6]. Risk of death from disability decreased for least advantaged men (RRR: 0.7, 95% CI 0.6-0.9); least advantaged women showed little improvement in transitions. IndLE patterns across time were similar.
Prevention should target the most disadvantaged areas, to narrow inequalities, with clear indication from the most advantaged that reduction in poor transitions is achievable.
尽管预期寿命(LE)不断延长,但许多国家的横断面数据显示,社会经济地位(SES)对无残疾预期寿命(DFLE)的不平等程度正在扩大。我们使用纵向数据更好地了解 SES 对 DFLE 和独立生活年限(IndLE)的趋势,以及潜在的转变如何发挥作用。
认知功能与衰老研究(CFAS I 和 II)是在英国三个中心(纽卡斯尔、诺丁汉、剑桥郡)针对年龄在 65 岁及以上人群的大型基于人群的研究,基线时间分别为 1991 年(CFAS I,n=7635)和 2011 年(CFAS II,n=7762),随访时间为 2 年。我们将日常生活活动(ADL)困难、ADL 和认知相结合反映所需护理的依赖以及按地区贫困程度划分的 SES 定义为残疾。通过多状态模型估计从残疾或依赖状态到死亡的转变。
在 1991 年至 2011 年间,最有利的男性和女性在 65 岁时的 DFLE 增益最大[男性:4.7 年,95%置信区间(95%CI)为 3.3-6.2;女性:2.8 年,95%CI 为 1.3-4.3]。增益是由于最有利的女性发生新发残疾的风险降低[相对风险比(RRR):0.7,95%CI 为 0.5-0.8],而最有利的男性更有可能康复(RRR:1.8,95%CI 为 1.0-3.2)和降低无残疾死亡率风险(RRR:0.4,95%CI 为 0.3-0.6]。最不利的男性残疾相关死亡率降低(RRR:0.7,95%CI 为 0.6-0.9);最不利的女性在转变方面几乎没有改善。随着时间的推移,IndLE 模式相似。
预防应针对最不利的地区,以缩小不平等差距,最有利的地区明确表明,减少不良转变是可行的。