Bernard A M, Amor A O, Lauwerys R R
Industrial Toxicology and Occupational Medicine Unit, University of Louvain, Brussels, Belgium.
Br J Ind Med. 1988 Feb;45(2):112-5. doi: 10.1136/oem.45.2.112.
Negative charges on red blood cell membranes were measured by the alcian blue binding test in 11 workers with high exposure to cadmium. Compared with 12 age matched control subjects, cadmium workers showed a significant decrease in red blood cell charge, which on average paralleled both the cadmium body burden and protein excretion. Animal data confirm these observations and also show that the loss of red blood cell charge caused by chronic cadmium poisoning is irreversible and associated with a loss of glomerular negative charges. The present study suggests thus that cadmium can increase the urinary excretion of anionic macromolecules such as albumin by reducing the glomerular polyanion charge.
通过阿尔辛蓝结合试验对11名镉高暴露工人的红细胞膜负电荷进行了测量。与12名年龄匹配的对照受试者相比，镉作业工人的红细胞电荷显著降低，平均而言，这与镉体内负荷和蛋白质排泄情况平行。动物数据证实了这些观察结果，还表明慢性镉中毒导致的红细胞电荷丧失是不可逆的，且与肾小球负电荷丧失有关。因此，本研究表明，镉可通过减少肾小球多阴离子电荷来增加阴离子大分子如白蛋白的尿排泄。
