Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Cancer Res Treat. 2021 Jul;53(3):641-649. doi: 10.4143/crt.2020.1212. Epub 2020 Dec 29.
Cancer-related fatigue is a common and distressing symptom that occurs during cancer treatment. This study aimed to find factors that are related to cancer-related fatigue, and its effect on patients' quality of life.
This study included 159 patients who completed questionnaires and interviews during their initial examination at the sleep clinic for cancer patients, Asan Medical Center, between December 2018 and January 2020. Their medical reports were reviewed retrospectively. Questionnaire data about depression, anxiety, insomnia, fear of disease progression, and dysfunctional beliefs about sleep, pain, and quality of life, were reviewed. Additionally, patient sleep structure data were analyzed.
Factors such as depression (p < 0.001), anxiety (p < 0.001), fear of cancer progression (p < 0.001), fatigue (p=0.027), and time in bed during 24 hours (p=0.037) were significant expecting variables for low quality of life from logistic regression analysis. In pathway analysis, depression (p < 0.001), not cancer-related fatigue (p=0.537), act as a direct risk factor on quality of life. And also, depression was an overall risk factor for insomnia, fatigue, and daily activity of cancer patients.
Cancer-related fatigue did not show significant effect on patient's quality of life in this study. However, the result of pathway analysis highlights the importance of assessing depression in the process of cancer treatment and providing appropriate interventions.
癌症相关疲劳是癌症治疗过程中常见且令人痛苦的症状。本研究旨在寻找与癌症相关疲劳相关的因素及其对患者生活质量的影响。
本研究纳入了 159 名患者，他们在 2018 年 12 月至 2020 年 1 月期间在首尔峨山医学中心癌症患者睡眠诊所首次就诊时完成了问卷调查和访谈。回顾性审查了他们的病历报告。审查了关于抑郁、焦虑、失眠、对疾病进展的恐惧以及对睡眠、疼痛和生活质量的功能失调信念的问卷数据。此外，还分析了患者的睡眠结构数据。
逻辑回归分析显示，抑郁（p<0.001）、焦虑（p<0.001）、对癌症进展的恐惧（p<0.001）、疲劳（p=0.027）和 24 小时卧床时间（p=0.037）等因素是生活质量低的预期变量。在路径分析中，抑郁（p<0.001）而不是癌症相关疲劳（p=0.537）是生活质量的直接风险因素。此外，抑郁是癌症患者失眠、疲劳和日常活动的总体风险因素。
在本研究中，癌症相关疲劳对患者的生活质量没有显著影响。然而，路径分析的结果强调了在癌症治疗过程中评估抑郁的重要性，并提供了适当的干预措施。
