Park Hana, Kang Danbee, Lee Tae Hoon, Oh Dongryul
Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, 06355, Korea.
Center for Clinical Epidemiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Support Care Cancer. 2025 Apr 14;33(5):379. doi: 10.1007/s00520-025-09371-3.
This study used a mobile-based assessment tool to evaluate the dynamics of distress and quality of life (QoL) in patients with esophageal, head and neck, and rectal cancers undergoing radiation therapy (RT).
A prospective cohort study was conducted between November 2022 and July 2023 and included 100 patients who had completed assessments at pre-RT, weeks 2, 4, and 6 of RT, and 1 month post-treatment. The National Comprehensive Cancer Network Distress Thermometer and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire were used.
All patients showed a 100% response rate to the mobile-based assessment at pre-RT, week 6, and post-treatment, with a 95% response rate at weeks 2 and 4 of RT. Of the 100 patients, 33% experienced marked distress pre-RT, with distress levels peaking at 67% at weeks 2 and 4. More than 50% of the patients reported experiencing sleep disturbance, fatigue, worry, or anxiety post-treatment. Their QoL dropped significantly during treatment from levels in weeks 2 and 4 and returned to pre-treatment levels post-RT. Higher distress was consistently correlated with poorer QoL. Emotional and physical issues such as pain and sleep disturbance were significantly associated with poor QoL pre- and post-RT.
RT was associated with increased distress and a temporary reduction in QoL. Key factors including sleep problems, fatigue, and emotional distress require targeted interventions to improve patient outcomes. Mobile technology use has proven effective in tracking distress and QoL in patients with cancer undergoing RT.
本研究使用一种基于移动设备的评估工具，来评估接受放射治疗（RT）的食管癌、头颈癌和直肠癌患者的痛苦程度动态变化及生活质量（QoL）。
于2022年11月至2023年7月进行了一项前瞻性队列研究，纳入了100例在放疗前、放疗第2周、第4周和第6周以及治疗后1个月完成评估的患者。使用了美国国立综合癌症网络痛苦温度计和欧洲癌症研究与治疗组织生活质量问卷。
所有患者在放疗前、第6周和治疗后对基于移动设备的评估的应答率为100%，在放疗第2周和第4周的应答率为95%。在这100例患者中，33%在放疗前经历了明显痛苦，在第2周和第4周痛苦水平达到峰值67%。超过50%的患者报告在治疗后出现睡眠障碍、疲劳、担忧或焦虑。他们的生活质量在治疗期间从第2周和第4周的水平显著下降，并在放疗后恢复到治疗前水平。更高的痛苦程度一直与较差的生活质量相关。疼痛和睡眠障碍等情绪和身体问题在放疗前后均与较差的生活质量显著相关。
放疗与痛苦增加和生活质量暂时下降有关。包括睡眠问题、疲劳和情绪困扰在内的关键因素需要有针对性的干预措施来改善患者的治疗结果。事实证明，使用移动技术可有效跟踪接受放疗的癌症患者的痛苦程度和生活质量。
