Department of Physics, University of Osijek, 31000 Osijek, Croatia.
Department of Physics, University of Osijek, 31000 Osijek, Croatia.
J Hazard Mater. 2021 May 5;409:124918. doi: 10.1016/j.jhazmat.2020.124918. Epub 2020 Dec 31.
Continuing our previous research work on a drug delivery system based on combined AC/DC magnetic fields, we have developed a prototype AC/DC magnetic syringe device for stimulation of drug release from drug carriers, with the options of injecting/removing drug carriers. The porous FeO carrier, in a dose-dependent manner, causes acute oxidative damage and reduces the viability of differentiated SH-SY5Y human neuroblastoma cells, indicating the necessity for its removal once it reaches the therapeutic concentration at the target tissue. The working mechanism of the device consists of three simple steps. First, direct injection of the drug adsorbed on the surface of a carrier via a needle inserted into the targeted area. The second step is stimulation of drug release using a combination of AC magnetic field (a coil magnetised needle with AC current) and permanent magnets (DC magnetic lens outside of the body), and the third step is removal of the drug carriers from the injected area after the completion of drug release by magnetising the tip of the needle with DC current. Removing the drug carriers allows us to avoid possible acute and long term side effects of the drug carriers in the patient's body, as well as any potential response of the body to the drug carriers.
延续我们之前关于基于交直流磁场的药物输送系统的研究工作，我们开发了一种用于刺激药物从药物载体中释放的交直流磁注射器原型设备，具有注射/去除药物载体的功能。多孔 FeO 载体以剂量依赖的方式导致急性氧化损伤，降低分化的 SH-SY5Y 人神经母细胞瘤细胞的活力，表明一旦载体在靶组织中达到治疗浓度，就有必要将其去除。该设备的工作机制包括三个简单的步骤。首先，通过插入目标区域的针将吸附在载体表面上的药物直接注射进去。第二步是使用交流磁场（带交流电流的磁化针线圈）和永磁体（体外的直流磁透镜）联合刺激药物释放，第三步是在药物释放完成后通过对针的尖端施加直流电流来将药物载体从注射区域中移除。移除药物载体可以避免药物载体在患者体内可能产生的急性和长期副作用，以及机体对药物载体的任何潜在反应。
