Pandey Popular, Ghimire Govinda, Garcia Javier, Rubfiaro Alberto, Wang Xuewen, Tomitaka Asahi, Nair Madhavan, Kaushik Ajeet, He Jin
Physics Department, Florida International University, Miami, Florida 33199, United States.
Department of Immunology and Nanomedicine, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, United States.
ACS Sens. 2021 Feb 26;6(2):340-347. doi: 10.1021/acssensors.0c00664. Epub 2020 Jun 8.
Magneto-electric nanoparticles (MENPs), composed of a piezoelectric shell and a ferromagnetic core, exhibited enhanced cell uptake and controlled drug release due to the enhanced localized electric field (surface charge/potential) and the generation of acoustics, respectively, upon applying alternating current (AC) magnetic (B)-field stimulation. This research, for the first time, implements an electrochemical single-entity approach to probe AC B-field induced strain mediated surface potential enhancement on MENP surface. The surface potential changes at the single-NP level can be probed by the open circuit potential changes of the floating carbon nanoelectrode (CNE) during the MENP-CNE collision events. The results confirmed that the AC B-field (60 Oe) stimulation caused localized surface potential enhancement of MENP. This observation is associated with the presence of a piezoelectric shell, whereas magnetic nanoparticles were found unaffected under identical stimulation.
磁电纳米颗粒（MENPs）由压电外壳和铁磁核心组成，由于在施加交变电流（AC）磁场（B）刺激时分别增强了局部电场（表面电荷/电位）和声子的产生，因而表现出增强的细胞摄取和可控的药物释放。本研究首次采用电化学单实体方法，来探究交流磁场诱导的应变介导的MENP表面电位增强。在MENP-CNE碰撞事件期间，浮动碳纳米电极（CNE）的开路电位变化能够探测单纳米颗粒水平的表面电位变化。结果证实，交流磁场（60奥斯特）刺激导致MENP的局部表面电位增强。这一观察结果与压电外壳的存在有关，而在相同刺激下，磁性纳米颗粒未受影响。
