Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, C4, 11, 68159, Mannheim, Germany.
Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, C4, 11, 68159, Mannheim, Germany.
Curr Opin Psychol. 2021 Feb;37:114-120. doi: 10.1016/j.copsyc.2020.12.002. Epub 2020 Dec 14.
Borderline personality disorder is most consistently characterized as a disorder of the experience and regulation of emotions. Neuropathological models have predominantly explained these clinical traits with an imbalance between prefrontal regulatory and limbic emotion generating structures. Here, we review the current evidential state of the fronto-limbic imbalance hypothesis of borderline personality disorder, based on task-related functional magnetic resonance imaging research. In turn, we discuss challenges to the notion that (1) amygdala hyperreactivity underlies emotional hyperreactivity and deficits in (2) prefrontal activity or (3) fronto-limbic connectivity underly emotion regulation deficits. We offer several suggestions to improve consolidation and interpretation of research in this area.
边缘型人格障碍最常被描述为一种情绪体验和调节障碍。神经病理学模型主要通过前额叶调节和边缘情绪产生结构之间的不平衡来解释这些临床特征。在这里，我们根据与任务相关的功能性磁共振成像研究，回顾了边缘型人格障碍的额-边缘不平衡假说的现有证据状态。反过来，我们讨论了以下观点所面临的挑战：(1)杏仁核反应过度是情绪反应过度的基础，以及(2)前额叶活动或(3)额-边缘连接不足是情绪调节缺陷的基础。我们提出了一些建议，以改善该领域研究的巩固和解释。
