Nguyen Thuy-Duong Thi, Jang Yong-Seok, Kim Yu-Kyoung, Kim Seo-Young, Lee Min-Ho, Bae Tae-Sung
Faculty of Odonto-Stomatology, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue City, Thua Thien Hue 530000, Vietnam.
Department of Dental Biomaterials and Institute of Biodegradable Material, Institute of Oral Bioscience, BK21 Plus Project, School of Dentistry, Jeonbuk National University, 567, Baekje-daero, Deokjin-gu, Jeonju 54896, Jeollabuk-do, South Korea.
ACS Biomater Sci Eng. 2019 Dec 9;5(12):6715-6724. doi: 10.1021/acsbiomaterials.9b01042. Epub 2019 Nov 11.
Guided bone regeneration using a perforated titanium membrane is actively used in oral and orthopedic surgeries to provide space for the subsequent filling of a new bone in the case of bone defects and to achieve proper bone augmentation and reconstruction. The surface modification of a titanium membrane using a strontium-substituted calcium phosphate coating has become a popular trend to provide better bioactivity and biocompatibility on the membrane for improving the bone regeneration because strontium can stimulate not only the differentiation of osteoblasts but also inhibit the differentiation of osteoclasts. The strontium-doped calcium phosphate coating on the titanium mesh was formed by the cyclic precalcification method, and its effects on bone regeneration were evaluated by in vitro analysis of osteogenesis-related gene expression and in vivo evaluation of osteogenesis of the titanium mesh using the rat calvarial defect model in this study. It was identified that the strontium-doped calcium phosphate-treated mesh showed a higher expression of all genes related to osteogenesis in the osteoblast cells and resulted in new bone formation with better osseointegration with the mesh in the rat calvarial defect, in comparison with the results of untreated and calcium phosphate-treated meshes.
在口腔和整形外科手术中，使用多孔钛膜引导骨再生被积极应用，以便在出现骨缺损时为后续新骨填充提供空间，并实现适当的骨增量和重建。使用锶取代的磷酸钙涂层对钛膜进行表面改性已成为一种流行趋势，因为锶不仅可以刺激成骨细胞的分化，还能抑制破骨细胞的分化，从而在膜上提供更好的生物活性和生物相容性，以促进骨再生。本研究中，通过循环预钙化法在钛网上形成了掺锶磷酸钙涂层，并通过体外成骨相关基因表达分析和使用大鼠颅骨缺损模型对钛网进行体内成骨评估，来评价其对骨再生的影响。结果表明，与未处理和磷酸钙处理的钛网相比，掺锶磷酸钙处理的钛网在成骨细胞中所有与成骨相关的基因表达更高，并且在大鼠颅骨缺损中形成了与钛网骨整合更好的新骨。
