Wu Shuang, Jang Yong-Seok, Lee Min-Ho
Department of Dental Biomaterials, Institute of Oral Bioscience, Institute of Biodegradable Material, School of Dentistry, Jeonbuk National University, Jeonju-si, South Korea.
Front Bioeng Biotechnol. 2021 Apr 29;9:652334. doi: 10.3389/fbioe.2021.652334. eCollection 2021.
Metallic biodegradable magnesium (Mg) is a promising material in the biomedical field owing to its excellent biocompatibility, bioabsorbability, and biomechanical characteristics. Calcium phosphates (CaPs) were coated on the surface of pure Mg through a simple alkali-hydrothermal treatment. The surface properties of CaP coatings formed on Mg were identified through wettability, direct cell seeding, and release tests since the surface properties of biomaterials can affect the reaction of the host tissue. The effect of CaP-coated Mg mesh on guided bone regeneration in rat calvaria with the critical-size defect was also evaluated using several comprehensive analyses in comparison with untreated Mg mesh. Following the application of protective CaP coating, the surface energy of Mg improved with higher hydrophilicity and cell affinity. At the same time, the CaP coating endowed Mg with higher Ca affinity and lower degradation. The Mg mesh with CaP coating had higher osteointegration and bone affinity than pristine Mg mesh.
金属可生物降解镁（Mg）因其优异的生物相容性、生物吸收性和生物力学特性，在生物医学领域是一种很有前景的材料。通过简单的碱 - 水热处理，将磷酸钙（CaPs）涂覆在纯镁表面。由于生物材料的表面性质会影响宿主组织的反应，因此通过润湿性、直接细胞接种和释放测试来确定在镁上形成的CaP涂层的表面性质。与未处理的镁网相比，还通过几种综合分析评估了CaP涂层镁网对大鼠颅骨临界尺寸缺损引导骨再生的影响。在施加保护性CaP涂层后，镁的表面能提高，亲水性和细胞亲和力增强。同时，CaP涂层使镁具有更高的钙亲和力和更低的降解率。与原始镁网相比，具有CaP涂层的镁网具有更高的骨整合性和骨亲和力。
