青少年非酒精性脂肪性肝病与肠道微生物群：两者有关系吗？
Non-alcoholic fatty liver disease and the gut microbiota in adolescents: is there a relationship?
机构信息
Pediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Tropical Medicine Departments, Faculty of Medicine, Tanta University, Tanta, Egypt.
出版信息
BMC Pediatr. 2024 Nov 29;24(1):779. doi: 10.1186/s12887-024-05268-y.
BACKGROUND
Despite the increasing prevalence of nonalcoholic fatty liver disease (NAFLD), the pathophysiology is still not fully understood. Recent evidence suggests that the gut microbiota may play a role in the pathophysiology of NAFLD and may also offer new therapeutic options.
METHODS
This prospective cross-sectional study included 100 consecutive newly diagnosed obese patients (BMI ≥ 95th percentile), aged 14-18 years with NAFLD (confirmed by ultrasound), persistently elevated levels of alanine aminotransferase (ALT) greater than 60 U/L for 1-6 months, and 100 healthy controls. We evaluated changes in the gut microbiota in NAFLD adolescents compared with healthy controls.
RESULTS
According to the multiple logistic regressions, the variables associated with NAFLD were the presence of Clostridium difficile, the presence of Salmonella spp., a greater abundance of Bifidobacterium and Prevotella, and a lower abundance of Lactobacillus.
CONCLUSION
Changes in the gut microbiota occur in adolescents with NAFLD compared with healthy individuals, which may be useful for identifying youths who are amenable to gut microbiota-based interventions.
CLINICAL TRIAL NUMBER
Not applicable.
背景
尽管非酒精性脂肪性肝病 (NAFLD) 的患病率不断增加，但发病机制仍未完全阐明。最近的证据表明，肠道微生物群可能在 NAFLD 的发病机制中起作用，并且还可能提供新的治疗选择。
方法
这项前瞻性横断面研究纳入了 100 例连续新诊断的肥胖患者（BMI≥第 95 百分位数），年龄在 14-18 岁之间，患有 NAFLD（超声证实），丙氨酸氨基转移酶（ALT）持续升高>60 U/L 1-6 个月，且有 100 名健康对照者。我们评估了 NAFLD 青少年与健康对照组之间肠道微生物群的变化。
结果
根据多因素逻辑回归分析，与 NAFLD 相关的变量包括艰难梭菌、沙门氏菌属的存在、双歧杆菌和普雷沃氏菌丰度增加以及乳酸杆菌丰度降低。
结论
与健康个体相比，NAFLD 青少年的肠道微生物群发生了变化，这可能有助于识别适合基于肠道微生物群的干预的青少年。
临床试验编号
不适用。
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