Pucca Manuela B, Franco Michelle V S, Medeiros Jilvando M, Oliveira Isadora S, Ahmadi Shirin, Cerni Felipe A, Zottich Umberto, Bassoli Bruna K, Monteiro Wuelton M, Laustsen Andreas H
Medical School, Federal University of Roraima, Boa Vista, RR, Brazil.
Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.
J Venom Anim Toxins Incl Trop Dis. 2020 Dec 14;26:e20200083. doi: 10.1590/1678-9199-JVATITD-2020-0083.
Snakebite envenoming can be a life-threatening condition, for which emergency care is essential. The (lancehead) genus is responsible for most snakebite-related deaths and permanent loss of function in human victims in Latin America. spp. venom is a complex mixture of different proteins that are known to cause local necrosis, coagulopathy, and acute kidney injury. However, the long-term effects of these viper envenomings have remained largely understudied.
Here, we present a case report of a 46-years old female patient from Las Claritas, Venezuela, who was envenomed by a snake from the genus. The patient was followed for a 10-year period, during which she presented oliguric renal failure, culminating in kidney failure 60 months after the envenoming.
In Latin America, especially in Brazil, where there is a high prevalence of envenoming, it may be relevant to establish long-term outpatient programs. This would reduce late adverse events, such as chronic kidney disease, and optimize public financial resources by avoiding hemodialysis and consequently kidney transplantation.
蛇咬伤中毒可能是一种危及生命的状况，对此进行紧急护理至关重要。矛头蝮属蛇类导致了拉丁美洲大多数与蛇咬伤相关的死亡以及人类受害者的永久性功能丧失。矛头蝮属蛇类的毒液是不同蛋白质的复杂混合物，已知会导致局部坏死、凝血病和急性肾损伤。然而，这些蝰蛇咬伤的长期影响在很大程度上仍未得到充分研究。
在此，我们报告一例来自委内瑞拉拉斯克拉里塔斯的46岁女性患者的病例，她被一条矛头蝮属蛇类咬伤中毒。该患者被跟踪观察了10年，在此期间她出现了少尿性肾衰竭，在中毒60个月后最终发展为肾衰竭。
在拉丁美洲，尤其是在巴西，矛头蝮属蛇类咬伤中毒的发生率很高，建立长期门诊项目可能具有重要意义。这将减少诸如慢性肾病等晚期不良事件，并通过避免血液透析以及随之而来的肾脏移植来优化公共财政资源。
