基于间充质干细胞的疗法对毒物诱导的肾病的肾保护作用

Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants.

作者信息

Lin Shujun, Lin Wenshan, Liao Chunling, Zhou Tianbiao

机构信息

Department of Nephrology, The Second Affiliated Hospital, Shantou University Medical College, 515041 Shantou, China.

出版信息

Stem Cells Int. 2020 Dec 21;2020:8819757. doi: 10.1155/2020/8819757. eCollection 2020.

DOI:10.1155/2020/8819757

PMID:33424979

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7773456/

Abstract

BACKGROUND

Renal damage caused by drug toxicity is becoming increasingly common in the clinic. Preventing and treating kidney damage caused by drug toxicity are essential to maintain patient health and reduce the social and economic burden. In this study, we performed a meta-analysis to assess the nephroprotective effect of mesenchymal stem cells (MSCs) in the treatment of kidney disease induced by toxicants.

METHODS

The Cochrane Library, Embase, ISI Web of Science, and PubMed databases were searched up to December 31, 2019, to identify studies and extract data to assess the efficacy of MSCs treatment of kidney disease induced by toxicants using Cochrane Review Manager Version 5.3. A total of 27 studies were eligible and selected for this meta-analysis.

RESULTS

The results showed that a difference in serum creatinine levels between the MSC treatment group and control group was observed for 2, 4, 5, 6-8, 10-15, 28-30, and ≥42 days (2 days: WMD = -0.88, 95% CI: -1.34, -0.42, = 0.0002; 4 days: WMD = -0.74, 95% CI: -0.95, -0.54, < 0.00001; 5 days: WMD = -0.46, 95% CI: -0.67, -0.25, < 0.0001; 6-8 days: WMD = -0.55, 95% CI: -0.84, -0.26, = 0.0002; 10-15 days: WMD = -0.37, 95% CI: -0.53, -0.20, < 0.0001; 28-30 days: WMD = -0.53, 95% CI: -1.04, -0.02, = 0.04; ≥42 days: WMD = -0.22, 95% CI: -0.39, -0.06, = 0.007). Furthermore, a difference in blood urea nitrogen levels between the MSC treatment group and control group was observed for 2-3, 4-5, 6-8, and ≥28 days. The results also indicate that MSC treatment alleviated inflammatory cells, necrotic tubules, regenerative tubules, and renal interstitial fibrosis in kidney disease induced by toxicants.

CONCLUSION

MSCs may be a promising therapeutic agent for kidney disease induced by toxicants.

摘要

背景

药物毒性所致肾损伤在临床上日益常见。预防和治疗药物毒性引起的肾损伤对于维护患者健康及减轻社会和经济负担至关重要。在本研究中，我们进行了一项荟萃分析，以评估间充质干细胞（MSC）在治疗毒物诱导的肾病中的肾保护作用。

方法

检索截至2019年12月31日的Cochrane图书馆、Embase、ISI科学网和PubMed数据库，以识别研究并提取数据，使用Cochrane系统评价软件5.3评估MSC治疗毒物诱导的肾病的疗效。共有27项研究符合条件并被选入本荟萃分析。

结果

结果显示，在第2、4、5、6 - 8、10 - 15、28 - 30和≥42天观察到MSC治疗组和对照组之间血清肌酐水平存在差异（第2天：加权均数差（WMD）=-0.88，95%可信区间（CI）：-1.34，-0.42，P = 0.0002；第4天：WMD=-0.74，95% CI：-0.95，-0.54，P < 0.00001；第5天：WMD=-0.46，95% CI：-0.67，-0.25，P < 0.0001；第6 - 8天：WMD=-0.55，95% CI：-0.84，-0.26，P = 0.0002；第10 - 15天：WMD=-0.37，95% CI：-0.53，-0.20，P < 0.0001；第28 - 30天：WMD=-0.53，95% CI：-1.04，-0.02，P = 0.04；≥42天：WMD=-0.22，95% CI：-0.39，-0.06，P = 0.007）。此外，在第2 - 3、4 - 5、6 - 8和≥28天观察到MSC治疗组和对照组之间血尿素氮水平存在差异。结果还表明，MSC治疗减轻了毒物诱导的肾病中的炎性细胞、坏死肾小管、再生肾小管和肾间质纤维化。