• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

枣（Mill.）通过激活Nrf2保护肝细胞免受酒精诱导的损伤。

Jujube ( Mill.) Protects Hepatocytes against Alcohol-Induced Damage through Nrf2 Activation.

作者信息

Hong Sungwha, Kim Younghwa, Sung Jeehye, Lee Hana, Heo Huijin, Jeong Heon Sang, Lee Junsoo

机构信息

Department of Food Science and Biotechnology, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea.

School of Food Biotechnology and Nutrition, Kyungsung University, Busan 48434, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2020 Dec 24;2020:6684331. doi: 10.1155/2020/6684331. eCollection 2020.

DOI:10.1155/2020/6684331
PMID:33424992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7781690/
Abstract

This study aimed at evaluating the cytoprotective activity of jujube water extract (JWE) against alcohol-induced oxidative stress via the activation of the Nrf2 pathway in HepG2 cells. JWE had various phenolic compounds, and the vanillic acid content was the highest in the extract. To determine the cytoprotective effect of JWE against alcohol-induced damage, hepatocytes were treated with JWE and 3% ethanol. JWE (100 g/mL) markedly increased cell viability by approximately 100% in a dose-dependent manner. Moreover, JWE attenuated the production of malondialdehyde, reactive oxygen species, aspartate, and alanine aminotransferase and the depletion of glutathione. Moreover, JWE enhanced the expression of antioxidant defense enzymes including heme oxygenase-1, NADPH quinone oxidoreductase 1, and -glutamate-cysteine ligase catalytic against alcohol-induced oxidative damage in hepatocytes via the activation of Nrf2. Taken together, JWE possesses the protective effect against alcohol-induced oxidative injury in hepatocytes through the upregulation of the Nrf2 signaling pathway. Therefore, jujube fruit might have the potential to improve alcohol-related liver problems.

摘要

本研究旨在通过激活HepG2细胞中的Nrf2途径，评估枣水提取物（JWE）对酒精诱导的氧化应激的细胞保护活性。JWE含有多种酚类化合物，其中香草酸含量在提取物中最高。为了确定JWE对酒精诱导损伤的细胞保护作用，用JWE和3%乙醇处理肝细胞。JWE（100μg/mL）以剂量依赖性方式显著提高细胞活力约100%。此外，JWE减轻了丙二醛、活性氧、天冬氨酸和丙氨酸转氨酶的产生以及谷胱甘肽的消耗。此外，JWE通过激活Nrf2增强了抗氧化防御酶的表达，包括血红素加氧酶-1、NADPH醌氧化还原酶1和γ-谷氨酸半胱氨酸连接酶催化亚基，以对抗酒精诱导的肝细胞氧化损伤。综上所述，JWE通过上调Nrf2信号通路对酒精诱导的肝细胞氧化损伤具有保护作用。因此，枣果可能具有改善酒精相关肝脏问题的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/7781690/0b682df1c821/ECAM2020-6684331.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/7781690/ac591ee3f2fa/ECAM2020-6684331.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/7781690/30251d5dc745/ECAM2020-6684331.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/7781690/ec6ce2a2cb3e/ECAM2020-6684331.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/7781690/1093fd746f01/ECAM2020-6684331.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/7781690/0b682df1c821/ECAM2020-6684331.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/7781690/ac591ee3f2fa/ECAM2020-6684331.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/7781690/30251d5dc745/ECAM2020-6684331.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/7781690/ec6ce2a2cb3e/ECAM2020-6684331.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/7781690/1093fd746f01/ECAM2020-6684331.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/7781690/0b682df1c821/ECAM2020-6684331.005.jpg

相似文献

1
Jujube ( Mill.) Protects Hepatocytes against Alcohol-Induced Damage through Nrf2 Activation.枣（Mill.）通过激活Nrf2保护肝细胞免受酒精诱导的损伤。
Evid Based Complement Alternat Med. 2020 Dec 24;2020:6684331. doi: 10.1155/2020/6684331. eCollection 2020.
2
A chemically standardized extract of Ziziphus jujuba fruit (Jujube) stimulates expressions of neurotrophic factors and anti-oxidant enzymes in cultured astrocytes.酸枣果实（枣）的化学标准化提取物可刺激培养的星形胶质细胞中神经营养因子和抗氧化酶的表达。
Phytother Res. 2014 Nov;28(11):1727-30. doi: 10.1002/ptr.5202. Epub 2014 Jul 28.
3
extract (Wuzhi Tablet) protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice.提取物（五酯片）通过调节小鼠的NRF2-ARE通路，预防慢性暴饮和急性酒精诱导的肝损伤。
Acta Pharm Sin B. 2017 Sep;7(5):583-592. doi: 10.1016/j.apsb.2017.04.002. Epub 2017 May 11.
4
Jujube-containing herbal decoctions induce neuronal differentiation and the expression of anti-oxidant enzymes in cultured PC12 cells.含枣的草药煎剂可诱导培养的PC12细胞发生神经元分化并促进抗氧化酶的表达。
J Ethnopharmacol. 2016 Jul 21;188:275-83. doi: 10.1016/j.jep.2016.05.015. Epub 2016 May 10.
5
Protective Effect of Flavonoids from Ziziphus jujuba cv. Jinsixiaozao against Acetaminophen-Induced Liver Injury by Inhibiting Oxidative Stress and Inflammation in Mice.金丝小枣叶总黄酮通过抑制氧化应激和炎症对乙酰氨基酚诱导的肝损伤的保护作用。
Molecules. 2017 Oct 20;22(10):1781. doi: 10.3390/molecules22101781.
6
Effect of Purple Sweet Potato Using Different Cooking Methods on Cytoprotection against Ethanol-Induced Oxidative Damage through Nrf2 Activation in HepG2 Cells.不同烹饪方法的紫薯对HepG2细胞中通过激活Nrf2抵抗乙醇诱导的氧化损伤的细胞保护作用。
Antioxidants (Basel). 2023 Aug 21;12(8):1650. doi: 10.3390/antiox12081650.
7
Self-protection against triptolide-induced toxicity in human hepatic cells via Nrf2-ARE-NQO1 pathway.通过 Nrf2-ARE-NQO1 通路防止雷公藤内酯醇诱导的人肝细胞毒性。
Chin J Integr Med. 2017 Dec;23(12):929-936. doi: 10.1007/s11655-017-2546-6. Epub 2017 May 18.
8
Isoflavone biochanin A, a novel nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element activator, protects against oxidative damage in HepG2 cells.染料木黄酮生物胆素 A，一种新型核因子红细胞 2 相关因子 2（Nrf2）-抗氧化反应元件激活剂，可防止 HepG2 细胞的氧化损伤。
Biofactors. 2019 Jul;45(4):563-574. doi: 10.1002/biof.1514. Epub 2019 May 27.
9
Hepatocyte-protective effect of nectandrin B, a nutmeg lignan, against oxidative stress: Role of Nrf2 activation through ERK phosphorylation and AMPK-dependent inhibition of GSK-3β.肉豆蔻木脂素nectandrin B对氧化应激的肝细胞保护作用：通过ERK磷酸化激活Nrf2及AMPK依赖性抑制GSK-3β的作用
Toxicol Appl Pharmacol. 2016 Sep 15;307:138-149. doi: 10.1016/j.taap.2016.08.003. Epub 2016 Aug 7.
10
Antioxidant Effect of Barley Sprout Extract via Enhancement of Nuclear Factor-Erythroid 2 Related Factor 2 Activity and Glutathione Synthesis.大麦苗提取物通过增强核因子-红细胞 2 相关因子 2 活性和谷胱甘肽合成的抗氧化作用。
Nutrients. 2017 Nov 16;9(11):1252. doi: 10.3390/nu9111252.

引用本文的文献

1
promotes fertility and pregnancy outcomes in Rat model of uterine adhesions.在大鼠子宫粘连模型中促进生育能力和妊娠结局。
Front Pharmacol. 2025 Jan 27;15:1496136. doi: 10.3389/fphar.2024.1496136. eCollection 2024.
2
Comparative Study on Hepatoprotective Effects of Traditional Herbs, Roots of Nakai, Fischer, Mill., and Fruits of Pall., on Ethanol-Induced Liver Injury in Mice.传统草药中井中根、费舍尔根、米尔根以及帕尔果实对小鼠酒精性肝损伤的保肝作用比较研究
Antioxidants (Basel). 2024 Sep 20;13(9):1137. doi: 10.3390/antiox13091137.
3
Effects of jujube ( mill.) fruit extracts on oxidative stress: A systematic review and meta-analysis of rodent studies.

本文引用的文献

1
Effects of heat treatment of mandarin peel on flavonoid profiles and lipid accumulation in 3T3-L1 adipocytes.热处理蜜橘皮对 3T3-L1 脂肪细胞中类黄酮谱和脂类积累的影响。
J Food Drug Anal. 2019 Jul;27(3):729-735. doi: 10.1016/j.jfda.2019.05.002. Epub 2019 May 29.
2
ERK/Nrf2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t-butylhydroperoxide-induced oxidative stress.没食子酸通过 ERK/Nrf2 通路激活减轻 t-丁基过氧化物诱导的氧化应激对 HepG2 细胞的肝损伤。
BMC Complement Altern Med. 2019 Jun 20;19(1):139. doi: 10.1186/s12906-019-2551-3.
3
Phenolic acid and flavonoid-rich fraction of Sasa quelpaertensis Nakai leaves prevent alcohol induced fatty liver through AMPK activation.
枣（Mill.）果实提取物对氧化应激的影响：对啮齿动物研究的系统评价和荟萃分析。
Food Sci Nutr. 2024 May 22;12(8):5312-5328. doi: 10.1002/fsn3.4234. eCollection 2024 Aug.
4
A Literature Review of the Pharmacological Effects of Jujube.枣的药理作用文献综述
Foods. 2024 Jan 6;13(2):193. doi: 10.3390/foods13020193.
5
Effect of Purple Sweet Potato Using Different Cooking Methods on Cytoprotection against Ethanol-Induced Oxidative Damage through Nrf2 Activation in HepG2 Cells.不同烹饪方法的紫薯对HepG2细胞中通过激活Nrf2抵抗乙醇诱导的氧化损伤的细胞保护作用。
Antioxidants (Basel). 2023 Aug 21;12(8):1650. doi: 10.3390/antiox12081650.
6
Hepatoprotective Effect of Dried Red Jujube Fruit Extract Against Acetaminophen-Induced Acute Hepatotoxicity.干红枣果实提取物对乙酰氨基酚诱导的急性肝毒性的保肝作用。
Cureus. 2023 Jan 2;15(1):e33272. doi: 10.7759/cureus.33272. eCollection 2023 Jan.
7
Comprehensive characterization of multiple components of using UHPLC-Q-Exactive Orbitrap Mass Spectrometers.使用超高效液相色谱- Q- 精确轨道阱质谱仪对多个成分进行全面表征。
Food Sci Nutr. 2022 Aug 9;10(12):4270-4295. doi: 10.1002/fsn3.3020. eCollection 2022 Dec.
8
Study on Masking the Bitterness of Chinese Medicine Decoction-Mate.中药配方颗粒苦味掩蔽的研究
Evid Based Complement Alternat Med. 2022 Sep 9;2022:3701288. doi: 10.1155/2022/3701288. eCollection 2022.
9
Improvement of antioxidant properties of jujube puree by biotransformation of polyphenols via fermentation.通过发酵对多酚进行生物转化改善枣泥的抗氧化性能
Food Chem X. 2022 Jan 17;13:100214. doi: 10.1016/j.fochx.2022.100214. eCollection 2022 Mar 30.
华西甜龙竹笋叶中富含酚酸和类黄酮的部分通过激活 AMPK 预防酒精性脂肪肝。
J Ethnopharmacol. 2018 Oct 5;224:335-348. doi: 10.1016/j.jep.2018.06.008. Epub 2018 Jun 12.
4
Protective Effect of Flavonoids from Ziziphus jujuba cv. Jinsixiaozao against Acetaminophen-Induced Liver Injury by Inhibiting Oxidative Stress and Inflammation in Mice.金丝小枣叶总黄酮通过抑制氧化应激和炎症对乙酰氨基酚诱导的肝损伤的保护作用。
Molecules. 2017 Oct 20;22(10):1781. doi: 10.3390/molecules22101781.
5
Naturally Occurring Nrf2 Activators: Potential in Treatment of Liver Injury.天然存在的Nrf2激活剂：在肝损伤治疗中的潜力。
Oxid Med Cell Longev. 2016;2016:3453926. doi: 10.1155/2016/3453926. Epub 2016 Dec 22.
6
Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases.洞悉氧化应激与炎症在肝脏疾病中的作用及相互依存关系
Oxid Med Cell Longev. 2016;2016:4234061. doi: 10.1155/2016/4234061. Epub 2016 Dec 14.
7
Nrf2 Knockdown Disrupts the Protective Effect of Curcumin on Alcohol-Induced Hepatocyte Necroptosis.Nrf2基因敲低破坏了姜黄素对酒精诱导的肝细胞坏死性凋亡的保护作用。
Mol Pharm. 2016 Dec 5;13(12):4043-4053. doi: 10.1021/acs.molpharmaceut.6b00562. Epub 2016 Oct 31.
8
Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases.离子通道与氧化应激作为肝脏疾病诊断或治疗的潜在联系
Oxid Med Cell Longev. 2016;2016:3928714. doi: 10.1155/2016/3928714. Epub 2016 Jan 5.
9
Cytoprotective Role of Nrf2 in Electrical Pulse Stimulated C2C12 Myotube.Nrf2在电脉冲刺激的C2C12肌管中的细胞保护作用。
PLoS One. 2015 Dec 14;10(12):e0144835. doi: 10.1371/journal.pone.0144835. eCollection 2015.
10
"Ziziphus jujuba": A red fruit with promising anticancer activities.“酸枣”：一种具有潜在抗癌活性的红色水果。
Pharmacogn Rev. 2015 Jul-Dec;9(18):99-106. doi: 10.4103/0973-7847.162108.