• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

使用超高效液相色谱- Q- 精确轨道阱质谱仪对多个成分进行全面表征。

Comprehensive characterization of multiple components of using UHPLC-Q-Exactive Orbitrap Mass Spectrometers.

作者信息

Qin Shi-Han, Yan Fang, E Shuai, Xiong Pei, Tang Su-Nv, Yu Kai-Quan, Zhang Min, Cheng Yung-Chi, Cai Wei

机构信息

School of Pharmacy Weifang Medical University Weifang China.

School of Pharmaceutical Sciences Hunan University of Medicine Huaihua China.

出版信息

Food Sci Nutr. 2022 Aug 9;10(12):4270-4295. doi: 10.1002/fsn3.3020. eCollection 2022 Dec.

DOI:10.1002/fsn3.3020
PMID:36514751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9731542/
Abstract

is the dried ripe fruit of the Rhamnaceae family; it is widely distributed in Shandong, Henan, Liaoning, and other places in China. In folk medicine, it was used to restore vital energy, as a blood tonic, and for the treatment of spleen deficiency. To date, a complete investigation of the compounds of has rarely been performed. Therefore, a reliable strategy based on UHPLC-Q-Exactive Orbitrap MS, combined with trace data acquisition mode (parallel reaction monitoring scanning, PRM) and multiple data processing methods, is necessary for the characterization of compounds in the Ultimately, 295 compounds, including 69 flavonoids, 60 alkaloids, 82 phenylpropanoids, 52 organic acids, and 32 other components, were identified in the ; of these, 270 have been reported in for the first time. This study provides deep insights into the chemistry of and could be useful for further studies aimed at identifying the factors contributing to the health benefits attributed to this fruit.

摘要

它是鼠李科植物的干燥成熟果实;在中国山东、河南、辽宁等地广泛分布。在民间医学中,它被用于恢复元气、作为补血剂以及治疗脾虚。迄今为止,对其化合物的全面研究很少进行。因此,基于超高效液相色谱-四极杆-静电场轨道阱质谱联用,结合痕量数据采集模式(平行反应监测扫描,PRM)和多种数据处理方法的可靠策略,对于该植物中化合物的表征是必要的。最终,在该植物中鉴定出295种化合物,包括69种黄酮类化合物、60种生物碱、82种苯丙素类化合物、52种有机酸和32种其他成分;其中,270种是首次在该植物中被报道。本研究为该植物的化学研究提供了深入见解,可能有助于进一步研究以确定该果实有益健康的因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2243/9731542/d92cd2ee9713/FSN3-10-4270-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2243/9731542/7f646bdff7da/FSN3-10-4270-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2243/9731542/d92cd2ee9713/FSN3-10-4270-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2243/9731542/7f646bdff7da/FSN3-10-4270-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2243/9731542/d92cd2ee9713/FSN3-10-4270-g002.jpg

相似文献

1
Comprehensive characterization of multiple components of using UHPLC-Q-Exactive Orbitrap Mass Spectrometers.使用超高效液相色谱- Q- 精确轨道阱质谱仪对多个成分进行全面表征。
Food Sci Nutr. 2022 Aug 9;10(12):4270-4295. doi: 10.1002/fsn3.3020. eCollection 2022 Dec.
2
In depth LC-ESIMS-guided phytochemical analysis of Ziziphus jujuba Mill. leaves.酸枣叶的 LC-ESIMS 引导的深入植物化学分析。
Phytochemistry. 2019 Mar;159:148-158. doi: 10.1016/j.phytochem.2018.12.014. Epub 2019 Jan 4.
3
Therapeutic Effects of Mill. Fruit in Traditional and Modern Medicine: A Review.《千年果在传统医学和现代医学中的治疗作用:综述》。
Med Chem. 2020;16(8):1069-1088. doi: 10.2174/1573406415666191031143553.
4
Transcriptome-wide expression analysis of gene family leads to functional characterization of flavonoid biosynthesis in fruit coloration of Mill.基因家族的全转录组表达分析有助于对枸杞果实着色过程中黄酮类生物合成进行功能表征。
Front Plant Sci. 2023 May 12;14:1171288. doi: 10.3389/fpls.2023.1171288. eCollection 2023.
5
Three new 8,4'-type oxyneolignans from the seeds of mill and their antitumor studies.从麻黄连轺种子中分离得到的三种新的 8,4'-型氧新木脂素及其抗肿瘤活性研究。
Nat Prod Res. 2023 May;37(9):1573-1576. doi: 10.1080/14786419.2021.2023144. Epub 2022 Jan 25.
6
Identification of Chemical Constituents in the Extract and Rat Serum from Ziziphus Jujuba Mill by HPLC-PDA-ESI-MSn.采用高效液相色谱-光电二极管阵列检测器-电喷雾电离串联质谱法鉴定酸枣提取物及大鼠血清中的化学成分
Iran J Pharm Res. 2014 Summer;13(3):1055-63.
7
Bioactive components in the fruits of Ziziphus jujuba Mill. against the inflammatory irritant action of Euphorbia plants.枣果实中的生物活性成分对大戟属植物炎性刺激作用的抑制。
Phytomedicine. 2012 Feb 15;19(3-4):239-44. doi: 10.1016/j.phymed.2011.09.071. Epub 2011 Oct 5.
8
Genetic analysis of mixed models of fruit sugar-acid fractions in a cross between jujube ( Mill.) and wild jujube ().枣(Mill.)与酸枣()杂交后代果实糖酸组分混合模型的遗传分析。
Front Plant Sci. 2023 May 12;14:1181903. doi: 10.3389/fpls.2023.1181903. eCollection 2023.
9
Metabolomics-based analysis of flavonoid metabolites in Chinese jujube and sour jujube fruits from different harvest periods.基于代谢组学的不同采收期中国枣和酸枣果实中类黄酮代谢物分析。
J Food Sci. 2022 Sep;87(9):3752-3765. doi: 10.1111/1750-3841.16290. Epub 2022 Aug 21.
10
Chloroplast genome sequence of the wild Mill. var from North China.华北野生变种的叶绿体基因组序列。
Mitochondrial DNA B Resour. 2021 Mar 1;6(2):666-667. doi: 10.1080/23802359.2021.1878962.

引用本文的文献

1
Chromatographic fingerprinting and antibiofilm effect of Ziziphus jujuba fraction on Pseudomonas aeruginosa.枣提取物对铜绿假单胞菌的色谱指纹图谱及抗生物膜作用
AMB Express. 2025 May 21;15(1):79. doi: 10.1186/s13568-025-01886-6.
2
Foods for Sleep Improvement: A Review of the Potential and Mechanisms Involved.改善睡眠的食物:潜在作用及相关机制综述
Foods. 2025 Mar 21;14(7):1080. doi: 10.3390/foods14071080.
3
LC-DAD-MS and HR-LC-QTOF Analysis of Ziziphus budhensis Leaves and Evaluation of Their In Vitro and In Vivo Biological Activities.

本文引用的文献

1
Chemical characterization, cytotoxic, antioxidant, antimicrobial, and enzyme inhibitory effects of different extracts from one sage ( L.) from Turkey: open a new window on industrial purposes.土耳其一种鼠尾草(L.)不同提取物的化学特征、细胞毒性、抗氧化、抗菌及酶抑制作用:为工业用途打开一扇新窗口。
RSC Adv. 2021 Jan 28;11(10):5295-5310. doi: 10.1039/d0ra10044g.
2
Innovative Biochemometric Approach to the Metabolite and Biological Profiling of the Balkan Thistle ( Griseb.), Asteraceae.菊科巴尔干蓟(Griseb.)代谢物和生物学特征分析的创新生物计量学方法
Plants (Basel). 2021 Sep 28;10(10):2046. doi: 10.3390/plants10102046.
3
酸枣叶的液相色谱-二极管阵列检测-质谱联用及高分辨液相色谱-四极杆飞行时间质谱分析及其体外和体内生物活性评价
Chem Biodivers. 2025 Aug;22(8):e202402835. doi: 10.1002/cbdv.202402835. Epub 2025 Jun 16.
4
Systematic identification of the chemical components of leaves and roots of Didymocarpus heucherifolius Hand.-Mazz. based on UHPLC Q-Exactive Orbitrap MS technology coupled with molecular networking strategy.基于超高效液相色谱-四极杆-轨道阱质谱技术结合分子网络策略对滇紫叶报春(Didymocarpus heucherifolius Hand.-Mazz.)叶和根的化学成分进行系统鉴定
Sci Rep. 2025 Jan 21;15(1):2617. doi: 10.1038/s41598-025-86802-5.
5
Lam. Bark and Leaves: Extraction, Phytochemical Composition, Bioassays and Studies.《榄仁树:树皮与树叶的提取、植物化学成分、生物测定及研究》
Plants (Basel). 2024 Aug 8;13(16):2195. doi: 10.3390/plants13162195.
6
Comparative prototypes and metabolites of Du-zhi pill in normal and cerebral ischemia rats by UHPLC-Q-TOF-MS/MS method.采用超高效液相色谱-四极杆飞行时间串联质谱法对正常及脑缺血大鼠杜仲丸的对照品及代谢产物进行研究。
Heliyon. 2024 Jan 20;10(3):e25059. doi: 10.1016/j.heliyon.2024.e25059. eCollection 2024 Feb 15.
7
Qualitative Analysis of Multiple Phytochemical Compounds in Tojapride Based on UHPLC Q-Exactive Orbitrap Mass Spectrometry.基于 UHPLC Q-Exactive Orbitrap 质谱法对托烷司琼中多种植物化学成分的定性分析。
Molecules. 2022 Oct 6;27(19):6639. doi: 10.3390/molecules27196639.
A rapid and sensitive LC-MS/MS method for the determination of vanillic acid in rat plasma with application to pharmacokinetic study.
一种用于测定大鼠血浆中香草酸的快速灵敏的液相色谱-串联质谱法及其在药代动力学研究中的应用。
Biomed Chromatogr. 2022 Jan;36(1):e5248. doi: 10.1002/bmc.5248. Epub 2021 Oct 14.
4
Molecular Networking Leveraging the Secondary Metabolomes Space of (Forsk.) Aschers. and (Ehrenb. ex Solms) Asch. in Tandem with Their Chemosystematics and Antidiabetic Potentials.分子网络联用对(Forsk.)Aschers. 和 (Ehrenb. ex Solms)Asch. 的次生代谢产物空间及其化学生态学和抗糖尿病潜力的研究
Mar Drugs. 2021 May 18;19(5):279. doi: 10.3390/md19050279.
5
Identification of Metabolites of Aurantio-Obtusin in Rats Using Ultra-High-Performance Liquid Chromatography-Q-Exactive Orbitrap Mass Spectrometry with Parallel Reaction Monitoring.采用超高效液相色谱-Q-Exactive 轨道阱质谱联用平行反应监测技术鉴定大鼠体内橙钝叶决明素的代谢产物
J Anal Methods Chem. 2021 Apr 15;2021:6630604. doi: 10.1155/2021/6630604. eCollection 2021.
6
Jujube ( Mill.) Protects Hepatocytes against Alcohol-Induced Damage through Nrf2 Activation.枣(Mill.)通过激活Nrf2保护肝细胞免受酒精诱导的损伤。
Evid Based Complement Alternat Med. 2020 Dec 24;2020:6684331. doi: 10.1155/2020/6684331. eCollection 2020.
7
Benzylisoquinoline alkaloid analysis using high-resolution Orbitrap LC-MS.使用高分辨轨道阱 LC-MS 进行苯并异喹啉生物碱分析。
J Mass Spectrom. 2021 Feb;56(2):e4683. doi: 10.1002/jms.4683.
8
Identification of the metabolites of isochlorogenic acid A in rats by UHPLC-Q-Exactive Orbitrap MS.采用 UHPLC-Q-Exactive Orbitrap MS 法鉴定大鼠中异绿原酸 A 的代谢物。
Pharm Biol. 2020 Dec;58(1):992-998. doi: 10.1080/13880209.2020.1822421.
9
Identification of the absorptive constituents and their metabolites in vivo of Ziziphi Spinosae Semen by UPLC-ESI-Q-TOF-MS/MS.基于超高效液相色谱-电喷雾串联四极杆飞行时间质谱联用技术鉴定酸枣仁在体内的吸收成分及其代谢产物
Biomed Chromatogr. 2020 Dec;34(12):e4965. doi: 10.1002/bmc.4965. Epub 2020 Aug 24.
10
Quality transitivity of Danhong Huayu Koufuye: A study on chemical profiles of medicinal herbs, compound preparation and dosed rat plasma using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.丹红化瘀口服液的质量传递性:基于超高效液相色谱-四极杆飞行时间质谱法对药材、复方制剂及给药大鼠血浆化学特征的研究
Biomed Chromatogr. 2020 May;34(5):e4813. doi: 10.1002/bmc.4813. Epub 2020 Mar 6.