He Yutong, Hou Honghao, Wang Shuqi, Lin Rurong, Wang Leyu, Yu Lei, Qiu Xiaozhong
Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Department of Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangdong, Guangzhou, 510515, China.
Guangdong Province Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China.
Bioact Mater. 2020 Dec 30;6(7):2000-2010. doi: 10.1016/j.bioactmat.2020.12.011. eCollection 2021 Jul.
Sea squirt, as a highly invasive species and main biofouling source in marine aquaculture, has seriously threatened the biodiversity and aquaculture economy. On the other hand, a conductive biomaterial with excellent biocompatibility, and appropriate mechanical property from renewable resources is urgently required for tissue engineering patches. To meet these targets, we presented a novel and robust strategy for sustainable development aiming at the marine pollution via recycling and upgrading the waste biomass-sea squirts and serving as a renewable resource for functional bio-scaffold patch in tissue engineering. We firstly demonstrated that the tunic cellulose derived natural self-conductive scaffolds successfully served as functional cardiac patches, which significantly promote the maturation and spontaneous contraction of cardiomyocytes both in vitro and enhance cardiac function of MI rats in vivo. We believe this novel, feasible and "Trash to Treasure" strategy to gain cardiac patches via recycling the waste biomass must be promising and beneficial for marine environmental bio-pollution issue and sustainable development considering the large-scale consumption potential for tissue engineering and other applications.
海鞘作为一种极具入侵性的物种以及海水养殖中主要的生物污损源，已严重威胁到生物多样性和水产养殖经济。另一方面，组织工程贴片迫切需要一种由可再生资源制成的、具有优异生物相容性和适当机械性能的导电生物材料。为实现这些目标，我们提出了一种新颖且稳健的可持续发展策略，旨在通过回收和升级废弃生物质——海鞘来解决海洋污染问题，并将其作为组织工程中功能性生物支架贴片的可再生资源。我们首先证明，从被囊纤维素衍生而来的天然自导电支架成功地用作功能性心脏贴片，这在体外显著促进了心肌细胞的成熟和自发收缩，并在体内增强了心肌梗死大鼠的心脏功能。考虑到组织工程及其他应用的大规模消费潜力，我们相信这种通过回收废弃生物质来获取心脏贴片的新颖、可行且“变废为宝”的策略，对于海洋环境生物污染问题和可持续发展必定是有前景且有益的。
