补充甲基化叶酸和甲钴胺（甲基化维生素B12）的癫痫合并亚甲基四氢叶酸还原酶（MTHFR）突变女性的妊娠结局
Pregnancy outcomes in women with epilepsy and MTHFR mutations supplemented with methylated folate and methylcobalamin (methylated B12).
作者信息
Lascar Emma M, Warner Nicole M, Doherty Michael J
机构信息
Department of Neuroscience, University of Washington, 1953 Pacific Ave, Seattle, WA, USA.
Swedish Epilepsy Center, Swedish Hospital, Seattle, WA, USA.
出版信息
Epilepsy Behav Rep. 2020 Dec 17;15:100419. doi: 10.1016/j.ebr.2020.100419. eCollection 2021.
Abstract
Antiseizure medications (ASM) may contribute to adverse fetal outcomes in pregnant women with epilepsy (WWE). Folate processing (Methylenetetrahydrofolate reductase, MTHFR) gene abnormalities are common in women with epilepsy and depression. L-methylfolate supplements may bypass MTHFR deficiencies, yet their use in WWE during gestation or on fetal development is not well studied. We examine pregnancy histories of three WWE who supplemented with either folate or L-methylfolate and methylcobalamin (methylated B12) during pregnancies. Their pregnancy outcomes improved with L-methylfolate and methylcobalamin supplementation. L-methylfolate and methylcobalamin supplementation merits further study in WWE who have MTHFR mutations, fertility, recurrent miscarriage and or depression histories.
摘要
抗癫痫药物（ASM）可能会导致癫痫孕妇（WWE）出现不良胎儿结局。叶酸代谢（亚甲基四氢叶酸还原酶，MTHFR）基因异常在癫痫和抑郁症女性中很常见。L-甲基叶酸补充剂可能绕过MTHFR缺陷，但它们在妊娠期WWE中的使用或对胎儿发育的影响尚未得到充分研究。我们研究了三名在孕期补充叶酸或L-甲基叶酸及甲钴胺（甲基化维生素B12）的WWE的妊娠史。补充L-甲基叶酸和甲钴胺后，她们的妊娠结局得到改善。对于有MTHFR突变、生育问题、复发性流产和/或抑郁症病史的WWE，补充L-甲基叶酸和甲钴胺值得进一步研究。
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