State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China; Joint Laboratory of Infinitus Quality Study of Chinese Herbal Medicine and National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Phytochemistry. 2021 Mar;183:112644. doi: 10.1016/j.phytochem.2020.112644. Epub 2021 Jan 9.
The genus Corydalis is a botanical source of various pharmaceutically active components. Its member species have been widely used in traditional medicine systems in Southeast Asia, especially in China for thousands of years. They have been administered to treat the common cold, hypertension, hepatitis, hemorrhage, edema, gastritis, cardiovascular and cerebrovascular diseases, and neurological disorders. Analgesia is the most important effect of Corydalis products, which are relatively non-addictive and associated with low tolerance compared with other analgesics. Certain Corydalis species are rich in alkaloids, which have strong biological activity, and also contain coumarins, flavonoids, steroids, organic acids and other chemical components. These constituents have pharmacological efficacy against diseases of the nervous, cardiovascular and digestive systems. Numerous investigations have been performed on these plants and their components. Here, we systemically summarized the chemical constituents of important medicinal member species of Corydalis that have been reported since 1962. A total 381 alkaloids were enumerated, including 117 quaternary isoquinoline type, 60 Benzophenanthridine type, 37 aporphine type, 10 protopine type, 59 phthalide isoquinoline type, 52 simple isoquinoline-type, 25 lignin amides and 21 other alkaloids. Thus, we have provided a basis for further explorations into the pharmacologically active constituents of Corydalissp.(Papaveraceae) to develop medicines that exert strong effects, are relatively non-addictive, and result in few side effects.
紫堇属是一个拥有各种药用活性成分的植物来源。其成员物种在东南亚的传统医学体系中，特别是在中国被广泛应用了数千年。它们被用于治疗感冒、高血压、肝炎、出血、水肿、胃炎、心血管和脑血管疾病以及神经紊乱。紫堇属植物的产品最重要的作用是止痛，与其他止痛药相比，它们相对不易上瘾，且耐受性较低。某些紫堇属物种富含生物碱，具有很强的生物活性，还含有香豆素、类黄酮、类固醇、有机酸和其他化学成分。这些成分对神经系统、心血管系统和消化系统的疾病具有药理功效。对这些植物及其成分进行了大量的研究。在这里，我们系统地总结了自 1962 年以来报道的紫堇属重要药用成员物种的化学成分。共列举了 381 种生物碱，包括 117 种季铵异喹啉型、60 种苯并菲啶型、37 种阿朴啡型、10 种原小檗碱型、59 种苯酞异喹啉型、52 种简单异喹啉型、25 种木质素酰胺和 21 种其他生物碱。因此，我们为进一步探索紫堇属（罂粟科）的具有强药效、不易上瘾且副作用少的药用活性成分提供了依据。
