• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

肺腺癌患者感染 SARS-CoV-2 的风险更高。

Lung adenocarcinoma patients have higher risk of SARS-CoV-2 infection.

机构信息

Bioengineering Institute of Chongqing University, Chongqing, China.

Chongqing Mix Biotechnology Co., Ltb, Chongqing, China.

出版信息

Aging (Albany NY). 2021 Jan 10;13(2):1620-1632. doi: 10.18632/aging.202375.

DOI:10.18632/aging.202375
PMID:33429366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7880402/
Abstract

Both lung adenocarcinoma and coronavirus disease 2019 would cause pulmonary inflammation. Angiotensin-converting enzyme 2, the functional receptor of SARS-CoV-2, also plays a key role in lung adenocarcinoma. To study the risk of SARS-CoV-2 infection in lung adenocarcinoma patients, mRNA and microRNA profiles were obtained from The Cancer Genome Atlas and Gene Expression Omnibus followed by bioinformatics analysis. A network which regards angiotensin-converting enzyme 2 as the center was structured. In addition, via immunological analysis to explore the essential mechanism of SARS-CoV-2 susceptibility in lung adenocarcinoma. Compared with normal tissue, angiotensin-converting enzyme 2 was increased in lung adenocarcinoma patients. Furthermore, a total of 7 correlated differently expressed mRNAs (ACE2, CXCL9, MMP12, IL6, AZU1, FCN3, HYAL1 and IRAK3) and 5 correlated differently expressed microRNAs (miR-125b-5p, miR-9-5p, miR-130b-5p, miR-381-3p and miR-421) were screened. Interestingly, the most frequent toll-like receptor signaling pathway was enriched by mRNA (interlukin 6) and miRNA (miR-125b-5p) sets simultaneously. In conclusion, it was assumed that miR-125b-5p-ACE2-IL6 axis could alter the risk of SARS-CoV-2 infection in lung adenocarcinoma patients.

摘要

肺腺癌和 2019 年冠状病毒病都会引起肺部炎症。血管紧张素转换酶 2（SARS-CoV-2 的功能受体）在肺腺癌中也起着关键作用。为了研究肺腺癌患者感染 SARS-CoV-2 的风险，我们从癌症基因组图谱和基因表达综合数据库中获得了肺腺癌患者的 mRNA 和 microRNA 谱，并进行了生物信息学分析。构建了以血管紧张素转换酶 2 为中心的网络。此外，通过免疫分析来探讨肺腺癌中 SARS-CoV-2 易感性的基本机制。与正常组织相比，肺腺癌患者的血管紧张素转换酶 2 增加。此外，筛选出 7 个差异表达的 mRNA（ACE2、CXCL9、MMP12、IL6、AZU1、FCN3 和 HYAL1）和 5 个差异表达的 microRNA（miR-125b-5p、miR-9-5p、miR-130b-5p、miR-381-3p 和 miR-421）。有趣的是，最常见的 Toll 样受体信号通路同时被 mRNA（白细胞介素 6）和 microRNA（miR-125b-5p）集富集。总之，假设 miR-125b-5p-ACE2-IL6 轴可以改变肺腺癌患者感染 SARS-CoV-2 的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e75/7880402/4e5f4086347d/aging-13-202375-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e75/7880402/26da68db3fa4/aging-13-202375-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e75/7880402/57aa71415f5b/aging-13-202375-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e75/7880402/4e5f4086347d/aging-13-202375-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e75/7880402/26da68db3fa4/aging-13-202375-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e75/7880402/57aa71415f5b/aging-13-202375-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e75/7880402/4e5f4086347d/aging-13-202375-g005.jpg

相似文献

1
Lung adenocarcinoma patients have higher risk of SARS-CoV-2 infection.肺腺癌患者感染 SARS-CoV-2 的风险更高。
Aging (Albany NY). 2021 Jan 10;13(2):1620-1632. doi: 10.18632/aging.202375.
2
Expression of SARS-COV-2 cell receptor gene ACE2 is associated with immunosuppression and metabolic reprogramming in lung adenocarcinoma based on bioinformatics analyses of gene expression profiles.基于基因表达谱的生物信息学分析，SARS-CoV-2 细胞受体基因 ACE2 的表达与肺腺癌中的免疫抑制和代谢重编程相关。
Chem Biol Interact. 2021 Feb 1;335:109370. doi: 10.1016/j.cbi.2021.109370. Epub 2021 Jan 7.
3
In Silico Identification of miRNA-lncRNA Interactions in Male Reproductive Disorder Associated with COVID-19 Infection.基于计算机的 COVID-19 感染相关男性生殖障碍中 miRNA-lncRNA 相互作用的鉴定。
Cells. 2021 Jun 12;10(6):1480. doi: 10.3390/cells10061480.
4
Computational Analysis of Targeting SARS-CoV-2, Viral Entry Proteins ACE2 and TMPRSS2, and Interferon Genes by Host MicroRNAs.宿主 microRNAs 对 SARS-CoV-2、病毒进入蛋白 ACE2 和 TMPRSS2 及干扰素基因的靶向计算分析。
Genes (Basel). 2020 Nov 16;11(11):1354. doi: 10.3390/genes11111354.
5
Expression Analyses of MicroRNAs in Hamster Lung Tissues Infected by SARS-CoV-2.SARS-CoV-2 感染仓鼠肺组织中 microRNAs 的表达分析。
Mol Cells. 2020 Nov 30;43(11):953-963. doi: 10.14348/molcells.2020.0177.
6
Identification of angiotensin-converting enzyme 2 (ACE2) protein as the potential biomarker in SARS-CoV-2 infection-related lung cancer using computational analyses.使用计算分析鉴定血管紧张素转换酶 2（ACE2）蛋白作为 SARS-CoV-2 感染相关肺癌的潜在生物标志物。
Genomics. 2020 Nov;112(6):4912-4923. doi: 10.1016/j.ygeno.2020.09.002. Epub 2020 Sep 8.
7
A new insight into sex-specific non-coding RNAs and networks in response to SARS-CoV-2.对 SARS-CoV-2 反应中性别特异性非编码 RNA 及网络的新认识。
Infect Genet Evol. 2022 Jan;97:105195. doi: 10.1016/j.meegid.2021.105195. Epub 2021 Dec 23.
8
Genomic, epigenomic, and immune subtype analysis of CTSL/B and SARS-CoV-2 receptor ACE2 in pan-cancer.全癌中CTSL/B和SARS-CoV-2受体ACE2的基因组、表观基因组和免疫亚型分析
Aging (Albany NY). 2020 Nov 20;12(22):22370-22389. doi: 10.18632/aging.104147.
9
Repurposing Methotrexate in Dampening SARS-CoV2-S1-Mediated IL6 Expression: Lessons Learnt from Lung Cancer.甲氨蝶呤在抑制 SARS-CoV2-S1 介导的 IL6 表达中的再利用：来自肺癌的经验教训。
Inflammation. 2022 Feb;45(1):172-179. doi: 10.1007/s10753-021-01536-6. Epub 2021 Sep 3.
10
High expression of ACE2 in the human lung leads to the release of IL6 by suppressing cellular immunity: IL6 plays a key role in COVID-19.人类肺部 ACE2 的高表达会通过抑制细胞免疫导致 IL6 的释放：IL6 在 COVID-19 中发挥关键作用。
Eur Rev Med Pharmacol Sci. 2021 Jan;25(1):527-540. doi: 10.26355/eurrev_202101_24425.

引用本文的文献

1
Clinical value of dysregulated miR-125b-5p in severe pneumonia children.失调的miR-125b-5p在重症肺炎儿童中的临床价值
BMC Immunol. 2025 Apr 12;26(1):31. doi: 10.1186/s12865-025-00707-6.
2
Unlike common pneumonia, COVID-19 is a risk factor for multiple cardiovascular diseases: A two-sample Mendelian randomization study.与普通肺炎不同，新冠病毒病是多种心血管疾病的一个风险因素：一项两样本孟德尔随机化研究。
Medicine (Baltimore). 2024 Dec 27;103(52):e41015. doi: 10.1097/MD.0000000000041015.
3
FCN3 inhibits the progression of hepatocellular carcinoma by suppressing SBDS-mediated blockade of the p53 pathway.

本文引用的文献

1
Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor.血管紧张素转化酶 2（ACE2）作为 SARS-CoV-2 的受体，其生理和病理调节。
Pharmacol Res. 2020 Jul;157:104833. doi: 10.1016/j.phrs.2020.104833. Epub 2020 Apr 14.
2
Clinical Characteristics of Coronavirus Disease 2019 in China.《中国 2019 年冠状病毒病临床特征》
N Engl J Med. 2020 Apr 30;382(18):1708-1720. doi: 10.1056/NEJMoa2002032. Epub 2020 Feb 28.
3
Adenosquamous carcinoma of the lung.肺腺鳞癌
FCN3 通过抑制 SBDS 介导的 p53 通路阻断来抑制肝细胞癌的进展。
Int J Biol Sci. 2023 Jan 1;19(2):362-376. doi: 10.7150/ijbs.69784. eCollection 2023.
4
Micro-Players of Great Significance-Host microRNA Signature in Viral Infections in Humans and Animals.意义重大的微观玩家-宿主 microRNA 特征在人类和动物的病毒感染中。
Int J Mol Sci. 2022 Sep 11;23(18):10536. doi: 10.3390/ijms231810536.
5
The Correlation Between Immune Invasion and SARS-COV-2 Entry Protein ADAM17 in Cancer Patients by Bioinformatic Analysis.生物信息学分析癌症患者免疫浸润与 SARS-CoV-2 进入蛋白 ADAM17 的相关性。
Front Immunol. 2022 Jun 3;13:923516. doi: 10.3389/fimmu.2022.923516. eCollection 2022.
6
A Novel Prognostic Signature for Survival Prediction and Immune Implication Based on SARS-CoV-2-Related Genes in Kidney Renal Clear Cell Carcinoma.基于肾透明细胞癌中与SARS-CoV-2相关基因的生存预测和免疫意义的新型预后特征
Front Bioeng Biotechnol. 2022 Jan 24;9:744659. doi: 10.3389/fbioe.2021.744659. eCollection 2021.
7
The role of microRNAs in solving COVID-19 puzzle from infection to therapeutics: A mini-review.微小 RNA 在解决新冠病毒感染到治疗的谜题中的作用：一篇迷你综述。
Virus Res. 2022 Jan 15;308:198631. doi: 10.1016/j.virusres.2021.198631. Epub 2021 Nov 14.
8
Association between prognostic factors and the outcomes of patients infected with SARS-CoV-2 harboring multiple spike protein mutations.与携带多个刺突蛋白突变的 SARS-CoV-2 感染患者预后因素及结局的关系。
Sci Rep. 2021 Nov 1;11(1):21352. doi: 10.1038/s41598-021-00459-4.
9
In Silico Identification of miRNA-lncRNA Interactions in Male Reproductive Disorder Associated with COVID-19 Infection.基于计算机的 COVID-19 感染相关男性生殖障碍中 miRNA-lncRNA 相互作用的鉴定。
Cells. 2021 Jun 12;10(6):1480. doi: 10.3390/cells10061480.
10
Intestinal expression of ACE2 in mice with high-fat diet-induced obesity and neonates exposed to maternal high-fat diet.高脂肪饮食诱导肥胖小鼠和母体高脂肪饮食暴露的新生儿肠道 ACE2 的表达。
Nutrition. 2021 Oct;90:111226. doi: 10.1016/j.nut.2021.111226. Epub 2021 Mar 7.
Onco Targets Ther. 2018 Aug 14;11:4829-4835. doi: 10.2147/OTT.S164574. eCollection 2018.
4
Angiotensin-converting enzyme 2 is a potential therapeutic target for EGFR-mutant lung adenocarcinoma.血管紧张素转换酶2是表皮生长因子受体突变型肺腺癌的一个潜在治疗靶点。
Biochem Biophys Res Commun. 2017 Jun 3;487(3):613-618. doi: 10.1016/j.bbrc.2017.04.102. Epub 2017 Apr 20.
5
Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and Inflammatory Lung Disease.肺血管紧张素转换酶2（ACE2）与炎症性肺病
Shock. 2016 Sep;46(3):239-48. doi: 10.1097/SHK.0000000000000633.
6
Angiotensin-converting enzyme 2 activator diminazene aceturate prevents lipopolysaccharide-induced inflammation by inhibiting MAPK and NF-κB pathways in human retinal pigment epithelium.血管紧张素转换酶2激活剂乙酰氨基阿维菌素通过抑制人视网膜色素上皮细胞中的丝裂原活化蛋白激酶和核因子κB信号通路来预防脂多糖诱导的炎症。
J Neuroinflammation. 2016 Feb 9;13:35. doi: 10.1186/s12974-016-0489-7.
7
A century old renin-angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology.一个有着百年历史的肾素-血管紧张素系统仍有着无尽的发展可能：心血管生理病理学中的AT1受体信号级联反应。
Cell Signal. 2014 Oct;26(10):2147-60. doi: 10.1016/j.cellsig.2014.06.011. Epub 2014 Jul 5.
8
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections.血管紧张素转换酶2可预防致死性甲型H5N1禽流感感染。
Nat Commun. 2014 May 6;5:3594. doi: 10.1038/ncomms4594.
9
Angiotensin-converting enzyme 2 and angiotensin 1-7: novel therapeutic targets.血管紧张素转换酶 2 和血管紧张素 1-7：新的治疗靶点。
Nat Rev Cardiol. 2014 Jul;11(7):413-26. doi: 10.1038/nrcardio.2014.59. Epub 2014 Apr 29.
10
Angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis protects against lung fibrosis by inhibiting the MAPK/NF-κB pathway.血管紧张素转换酶 2/血管紧张素-(1-7)/Mas 轴通过抑制 MAPK/NF-κB 通路来保护肺纤维化。
Am J Respir Cell Mol Biol. 2014 Apr;50(4):723-36. doi: 10.1165/rcmb.2012-0451OC.