Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410068 Oradea, Romania.
Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410068 Oradea, Romania.
Molecules. 2021 Jan 8;26(2):283. doi: 10.3390/molecules26020283.
(1) The metabolic syndrome (MS) promotes acute and chronic infections, due to the pro-inflammatory condition given by TNFα and IL6 or by affecting the microbiota. MS is also correlated with insulin resistance, causing inflammation and infections throughout the organism. (2) The purpose of this study was to track the effect of using the essential oil of L. (EOO) as an antibacterial treatment, compared to allopathic treatment with antibiotics in MS patients. A group of 106 people with MS was divided into four subgroups: L1-staphylococcal infection group, L2- infection group, L3-streptococcal infection group with EOO treatment, and CG-control group without infection or treatment. (3) EOO is responsible for the antibacterial effect, and reduced minor uncomplicated infections. After a 10-day treatment, intestinal side effects were absent, improving the phase angle. (4) The results suggest that EOO may exhibit an antibacterial effect, similar to the antibiotic treatment, without promoting MS-specific dysbiosis, and it also improves the phase angle in patients, which is used as an index of health and cellular function.
(1) 代谢综合征（MS）会导致促炎状态，从而促进急性和慢性感染，这种促炎状态是由 TNFα 和 IL6 引起的，或者是由其对微生物组的影响引起的。MS 还与胰岛素抵抗相关，会导致机体全身的炎症和感染。
(2) 本研究旨在追踪使用薰衣草精油（EOO）作为抗菌治疗的效果，与 MS 患者的抗生素常规治疗进行对比。一组 106 名 MS 患者被分为四个亚组：L1-葡萄球菌感染组、L2-感染组、L3-链球菌感染并用 EOO 治疗组和 CG-无感染或治疗的对照组。
(3) EOO 具有抗菌作用，并减少了轻微的非复杂性感染。经过 10 天的治疗，没有出现肠道副作用，相位角得到改善。
(4) 结果表明，EOO 可能具有类似于抗生素治疗的抗菌作用，而不会促进 MS 特异性的菌群失调，并且它还可以改善患者的相位角，相位角被用作健康和细胞功能的指标。
