Food and Pharmacy College, Zhejiang Ocean University, Zhejiang, Zhoushan 316022, China.
Mini Rev Med Chem. 2021;21(16):2261-2275. doi: 10.2174/1389557521666210111145011.
Quinoline, isoquinoline, and indoles are common heterocyclic compounds. They have many biological activities, such as antioxidant, anti-inflammatory, antibacterial, antitumor, anti-virus, anti-rheumatism, immunity regulation, expectorant, and analgesic. Over the past few centuries, traditional natural products have made great contributions to the discovery and development of new therapeutic agents. Many important drugs have been found from these three classes of compounds. In this mini-review, we mainly cover the research progress on antioxidant, anti-inflammatory, antibacterial, analgesic activities of quinoline, isoquinoline, and indole compounds over the past 20 years (2000- 2019). We aim to explore new characteristic groups or structures in the search for active lead compounds and provide a basis for rational drug design.
喹啉、异喹啉和吲哚是常见的杂环化合物。它们具有多种生物活性，如抗氧化、抗炎、抗菌、抗肿瘤、抗病毒、抗风湿、免疫调节、祛痰和镇痛。在过去的几个世纪里，传统的天然产物为发现和开发新的治疗药物做出了巨大贡献。许多重要的药物都来自这三类化合物。在这个小型综述中，我们主要涵盖了过去 20 年（2000-2019 年）喹啉、异喹啉和吲哚类化合物在抗氧化、抗炎、抗菌、镇痛活性方面的研究进展。我们旨在探索新的特征基团或结构，以寻找活性先导化合物，并为合理药物设计提供依据。
