Jokipii L, Miettinen A, Jokipii A M
Department of Serology and Bacteriology, University of Helsinki, Finland.
J Clin Microbiol. 1988 Jan;26(1):121-5. doi: 10.1128/jcm.26.1.121-125.1988.
The significance of serum antibodies binding to cysts of Giardia lamblia was evaluated by indirect immunofluorescence. Titers of 10 or higher were found in 85.6% of adults, who had probably never had giardiasis. Titers in 118 adults (geometric mean, 29.9) were higher than in 35 children (16.4), and titers in women (42.3) were higher than in men (20.0). Titers in 150 patients with primary giardiasis (80.4) were higher than in control adults, but overlapping precluded serological diagnosis. Titers increased with the duration of infection. Female patients had higher titers (100.5) than did males (66.1), but men who had been infected longer than 45 days had high titers (132). Titers in second serum samples taken from 26 patients 2 weeks to 3 months after successful nitroimidazole treatment (58.1) were lower than before treatment (151.7) but higher than in 118 controls. We conclude that most people have antibodies which cross-react with G. lamblia but which are induced by other immunogens and that primary giardiasis induces protracted systemic antibody responses.
通过间接免疫荧光法评估血清抗体与蓝氏贾第鞭毛虫囊肿结合的意义。在可能从未患过贾第虫病的85.6%的成年人中发现滴度为10或更高。118名成年人的滴度（几何平均值为29.9）高于35名儿童（16.4），女性的滴度（42.3）高于男性（20.0）。150名原发性贾第虫病患者的滴度（80.4）高于对照成年人，但滴度重叠使得血清学诊断受限。滴度随感染持续时间增加。女性患者的滴度（100.5）高于男性（66.1），但感染超过45天的男性滴度较高（132）。从26名患者在成功进行硝基咪唑治疗后2周 至3个月采集的第二份血清样本中的滴度（58.1）低于治疗前（151.7），但高于118名对照。我们得出结论，大多数人具有与蓝氏贾第鞭毛虫发生交叉反应的抗体，但这些抗体是由其他免疫原诱导产生的，并且原发性贾第虫病会引发持久的全身抗体反应。
