Devi K Bavya, Tripathy Bipasa, Kumta Prashant N, Nandi Samit Kumar, Roy Mangal
Department of Metallurgical and Materials Engineering, Indian Institute of Technology-Kharagpur, Kharagpur 721302, India.
Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata 700037, India.
ACS Biomater Sci Eng. 2018 Jun 11;4(6):2126-2133. doi: 10.1021/acsbiomaterials.8b00297. Epub 2018 May 9.
Magnesium-based bioceramics have emerged as a new class of biodegradable bone replacement material due to their higher degradation and good cytocompatibility. In the current research, we have prepared pure and zinc-doped magnesium silicate (MgS) bioceramics by solid state method and evaluated the in vitro degradability and in vivo biocompatibility. In vitro degradation of the MgS bioceramics was assessed in simulated body fluid (SBF) which showed enhanced degradability for 0.5 wt % Zn doped MgS samples. The in vivo biocompatibility was evaluated by implanting the samples in rabbit femur critical size defect. All the MgS samples were well-integrated at the host tissue site as evident in 90 day radiographic images and micro computed tomography (μ-CT). Oxytetracycline labeling indicated that 0.5 wt % Zn doped MgS samples had better bone regeneration after 90 days of implantation as compared to pure and 0.25 wt % Zn-doped samples. Any systemic and organ toxicity was negated by normal vital organ (heart, kidney, and liver) histology at 90 days.
镁基生物陶瓷因其较高的降解性和良好的细胞相容性，已成为一类新型的可生物降解骨替代材料。在当前的研究中，我们通过固态法制备了纯的和锌掺杂的硅酸镁（MgS）生物陶瓷，并评估了其体外降解性和体内生物相容性。在模拟体液（SBF）中评估了MgS生物陶瓷的体外降解情况，结果表明，0.5 wt%锌掺杂的MgS样品的降解性增强。通过将样品植入兔股骨临界尺寸缺损处来评估体内生物相容性。在90天的X射线图像和微型计算机断层扫描（μ-CT）中可以明显看出，所有MgS样品在宿主组织部位都很好地整合在一起。土霉素标记表明，与纯的和0.25 wt%锌掺杂的样品相比，0.5 wt%锌掺杂的MgS样品在植入90天后具有更好的骨再生能力。90天时正常重要器官（心脏、肾脏和肝脏）的组织学检查排除了任何全身和器官毒性。
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