Niu Yumiao, Du Tianming, Liu Youjun
Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.
J Funct Biomater. 2023 Apr 11;14(4):212. doi: 10.3390/jfb14040212.
Bone has a special structure that is both stiff and elastic, and the composition of bone confers it with an exceptional mechanical property. However, bone substitute materials that are made of the same hydroxyapatite (HA) and collagen do not offer the same mechanical properties. It is important for bionic bone preparation to understand the structure of bone and the mineralization process and factors. In this paper, the research on the mineralization of collagen is reviewed in terms of the mechanical properties in recent years. Firstly, the structure and mechanical properties of bone are analyzed, and the differences of bone in different parts are described. Then, different scaffolds for bone repair are suggested considering bone repair sites. Mineralized collagen seems to be a better option for new composite scaffolds. Last, the paper introduces the most common method to prepare mineralized collagen and summarizes the factors influencing collagen mineralization and methods to analyze its mechanical properties. In conclusion, mineralized collagen is thought to be an ideal bone substitute material because it promotes faster development. Among the factors that promote collagen mineralization, more attention should be given to the mechanical loading factors of bone.
骨骼具有一种特殊结构，既坚硬又有弹性，且骨骼的组成赋予其卓越的力学性能。然而，由相同的羟基磷灰石（HA）和胶原蛋白制成的骨替代材料却不具备相同的力学性能。了解骨骼结构、矿化过程及影响因素对于仿生骨的制备至关重要。本文就近年来胶原蛋白矿化在力学性能方面的研究进行综述。首先，分析骨骼的结构和力学性能，并描述不同部位骨骼的差异。然后，根据骨修复部位建议不同的骨修复支架。矿化胶原蛋白似乎是新型复合支架的更佳选择。最后，介绍制备矿化胶原蛋白最常用的方法，总结影响胶原蛋白矿化的因素及其力学性能分析方法。总之，矿化胶原蛋白被认为是一种理想的骨替代材料，因为它能促进更快的发育。在促进胶原蛋白矿化的因素中，应更多关注骨骼的机械负荷因素。
